从热加工食品中进行先进的糖化最终产品的固态微提取的共价有机框架的合理选
Xiao-Fan Lu1, Xin-Yu Li2, Rongyu Wang3
1College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan 250014, China.
Food chemistry
|May 21, 2025
概括
研究人员开发了一种使用计算化学的新方法,以找到在食品中检测高级糖化终产品 (AGEs) 的最佳材料. 这有助于监测与慢性疾病相关的AGE.
科学领域:
- 食品化学 食品化学
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 在食品的热加工过程中,先进的糖化最终产品 (AGEs) 形成.
- 增加AGE与慢性疾病风险有关.
- 对食品中AGE的有效监测对公共健康至关重要.
研究的目的:
- 在合成前使用计算方法预测和选适合AGEs的吸附剂.
- 开发一种有效的固相微提取 (SPME) 方法,用于检测加工食品中的AGE.
- 为食品分析中吸附剂选提供一个新的平台.
主要方法:
- 密度函数理论 (DFT) 用于计算10个COF和2个AGE之间的结合能量.
- 化共价有机框架 (BrCOF) 的合成和特征.
- BrCOF被用作AGE丰富的SPME涂层,其次是UHPLC-MS/MS检测.
主要成果:
- 由于协同效应,BrCOF与AGE表现出强烈的结合亲缘关系.
- 开发的SPME-UHPLC-MS/MS方法显示出出色的线性范围 (0.05-500 ng mL-1) 和低检测极限 (0.001 ng mL-1).
- 基于BrCOF的SPME方法的性能优于商业吸附剂和现有方法.
结论:
- BrCOF是热加工食品中AGE的SPME的高效吸收剂.
- DFT是用于预测和选SPME应用的吸附剂的宝贵工具.
- 这项研究提出了一个有前途的分析策略,用于复杂的食品矩阵中监测AGE.
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