探索维生素D通路基因多态性,维生素D状态和抑郁症之间的相互作用:基于人口的研究
Thaís da Silva Sabião1, Luiz Antônio Alves de Menezes-Júnior1, Aline Priscila Batista2
1School of Nutrition, Postgraduate Program in Health and Nutrition, Research and Study Group on Nutrition and Public Health (GPENSC), Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Nutrition (Burbank, Los Angeles County, Calif.)
|May 21, 2025
概括
维生素D缺乏可能会增加遗传敏感的个体的抑郁风险,这些个体的皮肤较暗,没有维生素D补充剂,阳光照射较低. 对于那些有风险的人来说,建议改变生活方式.
科学领域:
- 营养神经科学 营养神经科学
- 遗传学 遗传学是一种遗传学.
- 公共卫生 公共卫生
背景情况:
- 由于遗传和环境因素,维生素D水平与抑郁症之间的联系仍在争论中.
- 之前的研究对维生素D在心理健康中的作用产生了相互矛盾的结果.
研究的目的:
- 调查维生素D缺乏和抑郁症状之间的联系.
- 探索遗传变异,皮肤色素和生活方式对这种关系的影响.
主要方法:
- 一项基于人口的横截面研究,在COVID-19大流行期间涉及1637名参与者.
- 通过患者健康问卷评估的抑郁症状-9;用血清水平定义的维生素D缺乏.
- 对维生素D缺乏的遗传风险得分是根据DHCR7,GC和VDR基因的多态性计算出来的.
主要成果:
- 总体而言,维生素D缺乏与抑郁症状之间没有直接联系.
- 相互作用显示,维生素D缺乏,皮肤不白,遗传风险得分高 (第三次) 的个体中抑郁症的患病率更高.
- 维生素D缺乏也与非补充剂使用者和阳光照射不足者的抑郁症状增加有关,特别是在基因风险得分较高的第三种动物中.
结论:
- 维生素D缺乏与特定亚组中抑郁症状的更高患病率有关:具有非白色皮肤的巴西遗传倾向者,不服用维生素D补充剂的人以及阳光照射不足的人.
- 这些发现强调了考虑遗传倾向,皮肤颜色和生活方式因素的重要性,以了解维生素D与抑郁症的联系.
- 建议包括为患有抑郁症状的风险较高的个体促进生活方式的改变.
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