用Ocrevus治疗的多发性硬化症患者的病毒特异性抗体反应
Nadia Zivlaei1, Daut Can Asani1, Nicole Hartwig Trier1
1Department of Neurology, Rigshospitalet Glostrup, Valdemar Hansens vej 13, 2600 Glostrup, Denmark.
对复发性复发性多发性硬化症 (RRMS) 的ocrelizumab (OCR) 治疗没有改变大多数病毒抗体水平. 然而,EBV EBNA1 IgG在RRMS患者中仍然很高,支持其在MS发展中的作用.
科学领域:
- 神经免疫学 神经免疫学
- 病毒学 病毒学
- 免疫治疗是一种免疫疗法.
背景情况:
- 多发性硬化症 (MS) 是一种中枢神经系统脱髓化的疾病.
- 像Ocrelizumab (OCR) 这样的B细胞消耗疗法对复发性复发性多发性硬化症 (RRMS) 有效,但机制尚不清楚.
- 病毒感染,特别是爱斯坦-巴尔病毒 (EBV),与MS发病和诊断有关.
研究的目的:
- 为了研究OCR对RRMS患者不同病毒的血清抗体水平的影响.
- 探索MS中病毒特异性抗体的诊断潜力.
主要方法:
- 从RRMS患者 (在OCR治疗前和期间) 和健康对照 (HCs) 的血清样本进行了分析.
- 与酶相关的免疫吸收试验 (ELISA) 用于量化针对11种不同病毒的IgG抗体.
- 组间的抗体水平和OCR治疗前/后的抗体水平进行了比较.
主要成果:
- 在RRMS患者中,EBV核抗原1 (EBNA1) IgG水平在基线显著升高,与HC患者相比,无论OCR治疗如何.
- OCR治疗没有显著改变大多数测试的病毒抗体水平.
- 在OCR治疗后观察到SARS-CoV-2尖端蛋白IgG水平的显著降低.
结论:
- 在RRMS患者中EBV EBNA1 IgG的升高支持EBV在MS病变发生和诊断价值中的作用.
- OCR对抗体水平的影响可能取决于时间,而SARS-CoV-2显示下降.
- 需要进一步的研究来阐明在MS治疗中B细胞枯竭的确切机制.
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