细胞平衡基因中的长寿和生存的遗传预测因素:一个病例对照研究
Vera Erdman1, Anna Petintseva2, Yanina Timasheva1
1Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa 450054, Russia; Bashkir State Medical University, Ufa 450008, Russia.
Gene
|May 21, 2025
概括
关键细胞平衡基因中的遗传变异与健康的长寿和在不同与年龄相关的疾病中生存有关. 特定的基因相互作用会影响男性和女性的死亡风险和保护作用.
科学领域:
- 遗传学 遗传学 是一个
- 老年学是指老年学的学科.
- 分子生物学分子生物学
背景情况:
- 长寿被定义为在一生中保持身体和精神健康.
- 缓解衰老有害影响的适应机制有助于长寿.
- 细胞平衡在衰老和寿命中起着至关重要的作用.
研究的目的:
- 研究细胞平衡基因中的遗传变异与临床衰老表型之间的关联.
- 识别与健康长寿相关的遗传标记.
- 探索IGF1,PIK3R1,AKT1,MTOR,NFE2L2,KEAP1,HIF1A,TP53和SIRT1等基因在衰老中的作用.
主要方法:
- 这是一项长达20年的随访研究,对3312名年龄在18-114岁的人进行了随访.
- 对细胞平衡基因 (IGF1,PIK3R1,AKT1,MTOR,NFE2L2,KEAP1,HIF1A,TP53,SIRT1) 中的遗传变异进行分析.
- 研究与临床衰老表型和健康寿命的关联.
主要成果:
- KEAP1 (rs1048290) CC基因型与男性的长寿和生存相关.
- AKT1 (rs3803304) C等位基因与女性的长寿和预防脑血管疾病有关.
- AKT1,NFE2L2,HIF1A和SIRT1变体之间的相互作用影响了男性和女性的生存率和死亡率.
结论:
- 在NFE2L2,KEAP1,SIRT1,AKT1和HIF1A的遗传变异与与年龄有关的疾病的生存有显著的关联.
- 基因相互作用在确定健康的长寿方面发挥着关键作用.
- 这些发现突出了促进健康衰老的干预措施的潜在遗传目标.
相关概念视频
Telomeres and Telomerase
5.0K
5.0K
Replicative Cell Senescence
3.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.6K
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
PI3K/mTOR/AKT Signaling Pathway
3.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.4K
Cancer Survival Analysis
315
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
315
Nature and Nurture
20.3K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.3K


