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基于铁的多草药配方对肺癌和结肠癌细胞系的抗癌潜力

Kiruthiga Karunamoorthy¹, Jaikumar Vasudevan¹

¹Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Chennai, Tamilnadu, 603110, India.

Journal of ethnopharmacology

|May 21, 2025

概括

这项研究验证了传统的草药配方Kantha Chenduram (KC) 作为对肺癌和结肠癌的强有力的抗癌剂. 它的安全性和抗炎作用表明它有可能用于临床试验.

科学领域:

民族医学和药物发现
材料科学和纳米技术材料科学和纳米技术
癌症生物学和治疗方法

背景情况:

古老的草药配方为新药发现提供了丰富的来源,但往往缺乏科学验证.
由于有限的经验证据,传统疗法如Kantha Chenduram (KC) 仍然未得到充分利用.

研究的目的:

为了科学地描述传统的草药配方Kantha Chenduram (KC).
评估KC对肺癌和结肠癌细胞系的体外抗癌疗效.
评估KC的安全性和抗炎功能.

主要方法:

使用先进的光谱和显微技术 (AFM,XRD,FTIR,SEM-EDX) 进行KC的全面表征.
在体外评估抗癌活性对A549 (肺) 和HT 29 (结肠) 癌细胞.
进行了亡,细胞循环,DNA碎片化和细胞毒性测试. 此外,还研究了抗炎作用.

主要成果:

KC由晶体铁和氧气颗粒 (200 nm7 μm) 组成.
观察到显著的抗癌活性,IC50值为24.75微克/毫升 (肺) 和28.8微克/毫升 (结肠).
KC诱导了亡,在肺癌中阻止了G0-G1细胞周期,并证明了具有强大的抗炎作用的有利安全性.

结论:

科学验证支持KC的抗癌特性和改善人类健康的潜力.
坎塔·钱德拉姆 (KC) 是进一步临床研究和潜在的全球应用的有希望的候选人.

关键词:

抗炎药物抗炎药物抗炎药物这是一种抗癌药物.这是一个apoptotic.钱德拉姆是什么意思草药配方在草药配方中这是一个死症.

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