幻觉和相关的感知现象在全身性红斑狼和炎症性关节炎:一个横截面混合方法研究研究
Arjoon Arunasalam1, Thomas A Pollak1, Avni Varshney1
1Institute of Psychiatry, Psychology and Neuroscience, King's College London, and South London and Maudsley NHS foundation trust, London, UK.
概括
系统性红斑狼 (SLE) 患者比炎症性关节炎 (IA) 患者有更多的幻觉,特别是视觉和嗅觉类型. 识别这些作为SARD症状有助于应对,但报告仍然是一个挑战.
科学领域:
- 神经科学是一个神经科学.
- 类风湿病学 类风湿病学
- 精神病学是一个精神病学.
背景情况:
- 系统性自身免疫性风湿性疾病 (SARDs) 可能导致神经精神症状,包括幻觉.
- 在SARD中幻觉往往被低估,并且在临床环境中未被识别.
- INSPIRE项目侧重于SARS中幻觉的流行,感官模式,洞察力,时间和情感价值.
研究的目的:
- 分析和比较系统性红斑狼 (SLE) 和炎症性关节炎 (IA) 患者的幻觉体验.
- 评估这些患者群体中幻觉的患病率,模式,洞察力,情感价值和时间.
主要方法:
- 使用混合方法,整合了来自横截面调查的定量数据 (n=1022) 和采访的定性数据.
- 使用Pearson的 χ2测试,对定量数据进行了描述性和比较性分析.
- 定性数据经过专题分析.
主要成果:
- 与IA患者相比,SLE患者报告的视觉,嗅觉,触觉和存在幻觉的终身患病率显著更高 (p<0.005).
- 听觉幻觉在SLE和IA患者之间没有显著差异 (p=0.071).
- 患有SLE的患者更有可能在睡眠过渡之外出现幻觉 (p=0.020);缺乏洞察力很少见.
结论:
- 在SLE中更高的幻觉患病率表明,与IA相比,幻觉对大脑的直接影响更大.
- 在SARD中,幻觉体验与神经疾病中的幻觉体验相似,而不是初级精神疾病.
- 了解这些幻觉是SLE潜在的直接影响,可以改善归因,治疗,应对和患者-临床医生沟通.
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