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成熟母乳代谢特征的差异基于输送方式和平价

Jiayue Tang¹, Cai Shen², Dan Yao¹

¹Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, College of Food Science and Engineering, Ningbo University, Ningbo, China.

The Journal of nutritional biochemistry

|May 21, 2025

概括

孕产妇的分娩方式和平价显著改变成熟人乳 (MHM) 代谢物概况. 这些差异,特别是脂肪酸生物合成的差异,可能会影响婴儿营养和长期健康结果.

科学领域:

人类牛奶的代谢组分.
母亲生理学和婴儿营养

背景情况:

人母乳 (HM) 是婴儿的最佳营养.
成熟人乳 (MHM) 的代谢物组成受到母亲因素的影响,如饮食,平价和分娩方式.
了解这些影响对于优化婴儿营养至关重要.

研究的目的:

调查孕产妇分娩方式和平价对MHM代谢物概况的影响.
为了确定特定的差异表达代谢物 (DEM) 和相关的代谢途径.

主要方法:

收集了32名母亲 (3-6个月产后) 的MHM样本,具有不同的平价和分娩方式.
使用气体染色学-质谱学 (GC-MS) 和液体染色学-质谱学 (LC-MS) 的非目标代谢分析.
统计分析了代谢物数据,以确定组之间的显著差异.

主要成果:

根据传递方式和平价 (95%置信区间) 观察到MHM代谢物概况的显著差异.
鉴定了119个与输送方式相关的DEM,主要与脂肪酸生物合成途径有关.
284个DEM被确定与平价相关,与ABC载体,癌症中的中央碳代谢和D-氨基酸代谢相关.

结论:

交付方式和平价明显影响成熟母乳的代谢成分.
观察到的代谢差异可能受到与分娩方式相关的荷尔蒙变化 (皮质醇,催产素) 的影响.
需要进一步的研究来阐明婴儿的长期健康影响,并完善营养指南.

关键词:

交付方式交付模式在GC-MS中使用GC-MS.人类的牛奶是人类的牛奶.这就是LC-MS.没有针对性的代谢组分.

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