Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

53
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
53
Humoral Immune Responses01:36

Humoral Immune Responses

71.1K
Overview
71.1K
Complementation Tests00:49

Complementation Tests

4.8K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
4.8K
Language and Cognition01:27

Language and Cognition

303
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
303

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Steroid profiling in congenital adrenal hyperplasia: comparing immunoassays and LC-MS/MS accuracy.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same author

Does broad autism phenotype traits affect mother-child interaction?: a cross-sectional study from Turkey.

International journal of developmental disabilities·2026
Same author

The discriminative role of angiopoietin-like protein-3 for metabolic syndrome in polycystic ovary syndrome.

Revista da Associacao Medica Brasileira (1992)·2026
Same author

Amino acids: Missing link in preeclampsia pathogenesis?

European journal of nutrition·2026
Same author

Unveiling Hidden Trauma: Age-Specific Acute Stress Responses in Children and Adolescents after the 2023 Turkey Earthquakes.

Journal of child & adolescent trauma·2026
Same author

Assessing the performance of EWMA and CUSUM algorithms in patient-based real-time quality control of electrolytes.

Clinical chemistry and laboratory medicine·2026

相关实验视频

Updated: May 23, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.7K

自闭症谱系障碍中的补充系统功能障碍:证据表明C1q和C3水平发生变化 (ASD中的补充系统功能障碍).

Meltem Günaydın1, Özlem Doğan2, Fatih Günay3

  • 1MD, Sanlıurfa City Hospital, Department of Child and Adolescent Psychiatry, Sanliurfa, TURKEY.

Acta neuropsychiatrica
|May 21, 2025
PubMed
概括

这项研究在患有自闭症谱系障碍 (ASD) 的儿童中发现了较低的血清C1q水平,这表明补体系统的改变可能导致ASD病理生理学. 降低C1q是ASD的重要预测因素.

关键词:
自闭症谱系障碍 自闭症谱系障碍在C1qq.C2 C2 这样就好了.C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3补充系统 补充系统神经免疫系统的调节失调.

更多相关视频

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

7.1K
Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

5.9K

相关实验视频

Last Updated: May 23, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.7K
Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

7.1K
Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

5.9K

科学领域:

  • 神经免疫学 神经免疫学
  • 发育神经科学的发展神经科学.

背景情况:

  • 自闭症谱系障碍 (ASD) 是一种神经发育状况,具有复杂的病因.
  • 新兴研究表明,免疫系统的调节失调,特别是补充系统,可能在ASD中起作用.
  • 具体补充蛋白在ASD病理生理学的参与需要进一步研究.

研究的目的:

  • 为了比较ASD儿童与健康对照者的关键补充蛋白 (C1q,C2,C3,C4,MBL,L-ficolin,hsCRP) 的血清水平.
  • 为了确定补充蛋白水平是否与ASD症状严重程度相关.
  • 为了确定潜在的辅助基于ASD的生物标志物.

主要方法:

  • 分析了44名患有自闭症儿童的血清样本和44名年龄/性别匹配的对照.
  • 酶相关免疫吸收试验 (ELISA) 用于量化补充蛋白度.
  • 标准化工具 (CARS,ABC,RBSC-R) 评估了ASD症状的严重程度.

主要成果:

  • 患有自闭症儿童的血清C1q水平显著降低 (p < 0.001) 和C3水平降低 (p = 0.033).
  • 在ASD组中观察到略高的C2水平 (p = 0.015).
  • 降低的C1q水平被确定为ASD的显著预测因素 (p = 0.001),但没有发现与症状严重程度的相关性.

结论:

  • 补充系统蛋白质的变化,特别是血清C1q的降低,与ASD有关.
  • 这些发现支持了补充系统功能障碍有助于ASD病理生理学的假设.
  • 在突触修剪和神经免疫调节中C1q的作用凸显了其在ASD中的潜在意义.