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几十年来丹麦孕妇的甲状腺功能低下症
Marco Juul Thomsen1,2, Nanna Maria Uldall Torp1,2, Allan Carlé2,3
1Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
The Journal of clinical endocrinology and metabolism
|May 21, 2025
概括
在强化后,在丹麦孕妇中,孕妇甲状腺功能低下的发病率和患病率显著增加. 观察到发生的区域差异,需要进一步调查潜在原因.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 生殖医学 生殖医学
背景情况:
- 全球强化计划旨在预防缺障碍.
- 有关摄入量增加和自身免疫性甲状腺功能低下症之间的潜在联系存在担忧.
- 了解强化对母亲甲状腺健康的影响至关重要.
研究的目的:
- 研究丹麦孕妇甲状腺功能低下的时间趋势.
- 评估丹麦全国盐化 (2000年实施) 之前和之后甲状腺功能低下的发生变化.
- 探索甲状腺功能低下症发病率和患病率的区域差异.
主要方法:
- 这是一项基于登记的全国性研究,涵盖了丹麦 (1997-2016) 的1,189,134例单独怀孕.
- 地理居住被用作摄入量的代理,将队列分为东丹麦和西丹麦.
- 通过Levothyroxine处方数据识别的孕产妇甲状腺功能低下症,分析发生率和患病率.
主要成果:
- 孕产妇甲状腺功能低下的发病率从1997年的0.48-0.55/1,000例怀孕增加到2016年的5.1-9.1/1,000例.
- 患病率也显著增加,从3.1-3.8/1,000 (1997-1999) 增加到15.8-24.5/1,000 (2013-2016). 患病率也大幅增加,从3.1-3.8/1,000 (1997-1999) 增加到15.8-24.5/1,000 (2013-2016). 患病率也大幅增加,从3.1-3.8/1,000 (1997-1999) 增加到15.8-24.5/1,000 (2013-2016). 患病率也大幅增加.
- 与西丹麦相比,在丹麦东部观察到更高的发病率和流行率.
结论:
- 在丹麦孕妇中,在20多年中,甲状腺功能低下症的显著增加被观察到.
- 甲状腺功能低下的区域差异表明对强化有不同的反应.
- 建议进行进一步的研究,以阐明这些观察到的趋势和区域差异背后的机制.
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