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根据药物状态的强迫症障碍中的海马和杏仁体子场体积
Ziphozihle Ntwatwa1, Christine Lochner2, Annerine Roos2
1From the Department of Psychiatry & Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa (Ntwatwa, Roos, Sevenoaks, van Honk, Groenewold, Stein, Ipser); the SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa (Lochner); the Department of Psychology, Utrecht University, Utrecht, The Netherlands (van Honk); the Department of Psychiatry and Department of Anatomy & Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands (Veltman, van den Heuvel); the Compulsivity Impulsivity and Attention program, Amsterdam Neuroscience, Amsterdam, The Netherlands (Veltman, van den Heuvel); the Bellvitge Biomedical Research Institute-IDIBELL, Department of Psychiatry, Bellvitge University Hospital, Department of Clinical Sciences, Bellvitge Campus, Universitat de Barcelona-UB, CIBERSAM, Carlos III Health Institute, Madrid, Spain (Menchón); the Bellvitge Biomedical Research Institute-IDIBELL, Department of Psychiatry, Bellvitge University Hospital, Department of Social Psychology and Quantitative Psychology, Institute of Neurosciences, Universitat de Barcelona-UB, CIBERSAM, Carlos III Health Institute, Madrid, Spain ( Soriano-Mas); the Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (Mataix-Cols); the Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden (Mataix-Cols); the Department of Clinical Sciences, Lund University, Lund, Sweden (Mataix-Cols); the Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine (Nakamae); the Institute of Human Behavioral Medicine Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea (Choi, Kim, Kwon); the Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea (Choi); the Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Batistuzzo, Hoexter, Miguel); the Department of Methods and Techniques in Psychology, Pontifical Catholic University, São Paulo, SP, Brazil (Batistuzzo); the SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa (Stein) ziphozihle.ntwatwa@uct.ac.za.
强迫症 (OCD) 在海马和杏仁体 (HA) 中的大脑差异取决于药物状态. 与对照人群相比,接受药物治疗的强迫症患者表现出较小的海马体和较大的杏仁体积.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
背景情况:
- 强迫症 (OCD) 的神经生物学与海马和桃体 (HA) 有关.
- 之前在强迫症中HA子领域的体积检测结果不一致.
- 对强迫症中特定的HA子场体积的研究是有限的.
研究的目的:
- 调查强迫症中海马和杏仁体内大脑体积的潜在异质性.
- 单独分析服药和不服药的强迫症患者的子场体积.
- 探索HA子场体积与强迫症症状严重程度之间的关联.
主要方法:
- 分析了381名强迫症患者和338名健康对照者的结构性MRI (T1加权图像).
- 海马和杏仁体的子领域使用Free-Surfer 6.0.0进行了细分.
- 混合效应模型,根据共变量进行调整,评估子领域体积的组间差异,并对多次比较进行FDR校正.
主要成果:
- 在强迫症患者和对照人群之间,整体HA子场体积没有显著差异.
- 服药的强迫症患者表现出较小的海马牙和分子层体积,以及较大的横向和基底杏仁体积.
- 与对照人群相比,没有药物治疗的强迫症患者表现出较小的海马角1部门体积.
结论:
- 强迫症的海马和杏仁体子场体积差异受精神药物治疗状态的影响.
- 这些发现凸显了在强迫症神经成像研究中考虑药物状态的关键需要.
- 截面数据限制了因果解释.

