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胃肠癌中的FAPI PET与FDG PET/CT:一个概述

Zhaoguo Lin¹, Pawel Rasinski², Ted Nilsson²

¹Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China; Hubei Key Laboratory of Molecular Imaging, Wuhan, China.

Seminars in nuclear medicine

|May 21, 2025

概括

与FDG PET相比,使用FAPI PET进行纤维细胞激活蛋白 (FAP) 成像可以提高胃肠癌的诊断准确度和治疗指导. FAPI PET提高了这些恶性瘤的检测和管理.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
分子成像学分子成像学

背景情况:

纤维细胞激活蛋白 (FAP) 在各种癌症的癌症相关纤维细胞 (CAF) 中过度表达,与预后不佳和治疗耐药性相关.
用于PET成像的放射标记FAP抑制剂 (FAPI) 在癌症中显示出临床效用,特别是在胃肠道 (GI) 恶性瘤中具有脱质反应.

研究的目的:

为了全面比较FAPI PET和[18F]FDG PET在肠道癌症中的诊断,分期和治疗指南.
审查FAPI PET在评估治疗反应和预测胃肠道恶性瘤的预后方面的不断扩大的作用.

主要方法:

对比FAPI PET和[18F]FDG PET在肠道癌症中的临床研究的综述.
分析FAPI PET在诊断,分期,治疗反应评估和预后预测方面的应用.

主要成果:

FAPI PET显示出作为[18F]FDG PET在肠道癌症中的补充方法的潜力,克服了像低灵敏度和高背景吸收等局限性.
在提高胃肠道恶性瘤的诊断准确性和治疗指导方面,FAPI PET显示出有前途.

结论:

FAPI PET具有显著的潜力,可以改善肠道恶性瘤的管理.
进一步了解FAPI PET在治疗反应和预后预测中的作用,预计将提高患者的护理.

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