免疫检查点抑制剂相关的乙性带炎:3个病例报告与文献综述

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Mélanie Biteau¹, Vincent Sibaud², Alexandre Maria³

¹Internal Medicine and Immunopathology Department, The Cancer University of Toulouse Oncopole, Toulouse University Hospital, 1, avenue Joliot-Curie, 31100 Toulouse, France.

La Revue de medecine interne

|May 21, 2025

概括

免疫检查点抑制剂 (ICI) 很少会导致酸性膜炎 (EF). 这项研究分析了30例病例,发现与异常性EF有相似之处,并为这种罕见的免疫相关不良事件提出了治疗算法.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

免疫检查点抑制剂 (ICI) 可以引起各种与免疫相关的不良事件 (irAEs).
乙酸性膜炎 (EF) 是一种与ICI相关的罕见的irAE,关于诊断和管理的数据有限.
现有的文献缺乏管理ICI相关EF (ICI-EF) 的明确指导方针.

研究的目的:

描述ICI-EF的临床和生物特征.
为了比较ICI-EF与异常病理EF.
为ICI-EF提出一个管理算法.

主要方法:

对符合皮纳尔-费尔南德斯标准的ICI-EF案件 (2016-2023) 的文献综述.
包括来自奥西塔尼亚地区的三个新病例.
对30个确诊病例的分析.

主要成果:

队列包括30名患者 (27名来自文献,3名新患者);男性占主导地位 (M/F比1.3),平均年龄57岁.
黑色素瘤是最常见的瘤 (50%),中位发病时间为10个月.
在73%的患者中存在过高氨基酸; 83%的患者接受了类固醇, 72%的患者需要免疫抑制剂; 2名患者的再试验显示没有复发.

结论:

在临床和生物学上,ICI-EF与异常性EF具有共同的特征.
管理与异常性EF一致,通常从皮质类固醇开始,经常需要二线免疫抑制剂.
建议ICI-EF采用积极的管理方法和特定的治疗算法.

关键词:

不良影响免疫诱导免疫诱导埃索诺菲尔性纤维炎是一种表皮炎.粘结在埃索诺菲尔菌中免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件.免疫学检查点的抑制剂舒尔曼病 (Maladie de Shulman) 是一个疾病.肌炎是一种肌炎.肌膜炎是一种肌膜炎.尼沃卢马布的使用情况佩姆布罗利兹马布的使用方法舒尔曼病是舒尔曼病的一种疾病.

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