对阿尔茨海默氏病的APP选择性BACE1抑制剂的发现

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Updated: May 23, 2025

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Jesus Campagna1, Barbara Jagodzinska1, Dongwook Wi1

  • 1Drug Discovery Lab (DDL), Department of Neurology, Easton Center for Alzheimer's Disease Research and Care, David Geffen School of Medicine, University of California, Los Angeles (UCLA), CA, 90095, USA.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
|May 21, 2025
PubMed
概括

研究人员开发了一种新的APP选择性BACE1抑制剂FAH65E,用于阿尔茨海默病. 这种选择性抑制剂降低了粉样β水平,并改善了小鼠的记忆力,显示出作为一流口服疗法的前景.

关键词:
在APP中选择性的APP.在ASBI的基础上,ASBI这是一种BACE1抑制剂.FAH65 FAH65 的时间

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