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Updated: May 23, 2025

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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Nsp1 阻断了 DNA 聚合酶 α 在 DNA 头上的作用

Andrey G Baranovskiy1, Lucia M Morstadt1, Nigar D Babayeva1

  • 1Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Scientific reports
|May 21, 2025
PubMed
概括

SARS-CoV-2 Nsp1蛋白质通过阻断DNA聚合酶α在发针结构上抑制人类DNA复制. 这种相互作用与原生体活动不同,突出了影响宿主DNA修复和复制的新型病毒机制.

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