焦虑在调节时间处理和自闭症谱系障碍中的感官过敏反应中的作用:一项fMRI研究
Takeshi Atsumi1,2, Masakazu Ide3, Mrinmoy Chakrabarty4,5
1Department of Medical Physiology, Kyorin University, Tokyo, Japan. atsumi-takeshi@ks.kyorin-u.ac.jp.
Scientific reports
|May 21, 2025
概括
焦虑可能会扰乱自闭症谱系障碍 (ASD) 中的情绪定时电路,影响感官处理. 在ASD中增加的焦虑与大脑活动的改变和感官过敏反应相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 自闭症谱系障碍 (ASD) 经常表现为非典型的感官特征和高焦虑并发症.
- 患有自闭症的个体表现出感官过敏反应,可能已经改变了时间处理.
- 焦虑在ASD中调节时间处理中的作用需要进一步调查.
研究的目的:
- 为了研究这种假设,高焦虑导致神经回路改变的时间感知和感官过度响应在ASD.
- 在ASD和典型发达 (TD) 参与者的情绪诱导视觉时间顺序判断任务期间检查神经活动.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估25名ASD患者和25名TD参与者的大脑活动.
- 参与者完成了一项由面部情绪引发的视觉时间顺序判断任务.
- 分析了焦虑水平,任务执行,感官超响应和神经激活之间的相关性.
主要成果:
- 恐惧的面部表情增强了TD参与者的时间处理,但不是ASD组.
- 在ASD组中,焦虑水平与情绪驱动的任务表现和感官过度反应相关.
- 焦虑调解了与自闭症患者的直角环激活和感官过敏反应之间的关系.
结论:
- 通过恐惧线索增强时间处理,一种情绪定时的神经电路,可能在ASD中被破坏.
- 在ASD中增加的焦虑和感官过敏反应可能与参与时间感知的大脑区域有关.
- 研究结果表明,焦虑在ASD中观察到的感官处理差异中起着调解作用.
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