相关实验视频

Updated: May 23, 2025

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

在多囊性卵巢综合征中,LXR通路驱动激素反应强度

Sarah Dallel^1,2,3,4, Manon Despalles^1,2,3,4, Margaux Tore^1,2,3,4

¹Université Clermont Auvergne, iGReD, CNRS UMR 6293, INSERM U1103, 28, place Henri Dunant, BP38, 63001, Clermont-Ferrand, France.

EMBO molecular medicine

|May 21, 2025

概括

肝脏X受体 (LXR) 调节卵巢对淋巴激素的反应,防止辅助生殖技术 (ART) 期间的炎症. 激活LXR可以防止异常的卵巢过度刺激,特别是在多囊性卵巢综合征 (PCOS) 患者中.

科学领域:

生殖内分泌学生殖内分泌学
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

在辅助生殖技术 (ART) 中的淋巴激素刺激可以在多囊性卵巢综合征 (PCOS) 患者中引起异常的卵巢过度刺激.
肝X受体 (LXR) 途径与调节卵巢对激素刺激的反应有关.

研究的目的:

调查LXR在调节卵巢炎症和淋巴激素刺激期间细胞反应中的作用.
探索链接固醇信号传递,炎症和免疫细胞透在卵巢中的分子机制.

主要方法:

利用小鼠模型研究LXR激活和缺乏对卵巢对淋巴激素的反应的影响.
检查了卵巢颗粒细胞中的基因表达,免疫细胞透和炎症标志物 (例如IL1β,TXNIP).
分析了接受ART的PCOS患者的累积卵细胞复合体.

主要成果:

药理LXR激活保护野生型小鼠免受淋巴激素过度刺激,模仿LXR缺乏的小鼠.
在小鼠中,LXR缺乏导致免疫细胞透的增加,改变了粒状细胞的反应,并在卵巢刺激期间增强了炎症.
LXR通过颗粒细胞中的TXNIP基因表达来调节炎症酶活性,控制IL1β的产生.
在PCOS患者的卵巢组织和积卵细胞复合体中观察到免疫细胞透,持续到排卵.

结论:

在ART中激素刺激期间,LXR在抑制炎症和调节颗粒细胞功能方面发挥着关键作用.
向LXR途径可能提供一种治疗策略,以减轻ART中的不良炎症反应,特别是对于PCOS患者.

关键词:

颗粒状细胞颗粒状细胞激素刺激激素刺激在炎症中,一些细胞会发炎.肝脏X受体肝脏X受体多囊性卵巢综合征多囊性卵巢综合征

更多相关视频

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

相关概念视频

Hormonal Regulation of the Menstrual Cycle

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...

Hormonal Control of the Ovarian Cycle

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...

Target Cell Response to Hormones

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...

Hormonal Regulation

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.

Ovarian Cycle

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...

Feedback Regulation of Calcium Concentration

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...