在并发性失眠和睡眠呼吸暂停 (COMISA) 中的心率变异性分析
Adrián Martín-Montero1,2, Fernando Vaquerizo-Villar1,2, Clara García-Vicente3,4
1Biomedical Engineering Group, University of Valladolid, Av. Ramón y Cajal, 7, Valladolid, 47003, Spain.
Scientific reports
|May 21, 2025
概括
伴随性失眠和睡眠呼吸暂停 (COMISA) 导致独特的夜间自主神经系统 (ANS) 功能障碍,在清醒期间的副交感活动较少,在睡眠期间的交感活动更多. 这不同于孤立的失眠或阻塞性睡眠呼吸暂停 (OSA).
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 神经科学是一个神经科学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和失眠是常见的睡眠障碍.
- 伴随性失眠和睡眠呼吸暂停 (COMISA) 描述了它们的同时发生.
- 自主神经系统 (ANS) 功能障碍与OSA和失眠有关,但COMISA的具体影响尚不清楚.
研究的目的:
- 用心率变化 (HRV) 分析在COMISA中描述夜间ANS变化.
- 为了区分COMISA相关的ANS变化与孤立失眠或OSA的变化.
主要方法:
- 分析了来自睡眠心脏健康研究 (SHHS) 数据集的5335张心电图.
- 参与者根据多睡眠和问卷被分为没有OSA,失眠,OSA或COMISA组.
- 时间和频率域HRV特征计算为清醒和睡眠周期.
主要成果:
- COMISA在清醒期间表现出降低的副交感活动,并在睡眠期间增加了同情激活.
- 在OSA和COMISA中经常出现的呼吸暂停事件会影响HRV频率特征.
- 失眠独特地改变了睡眠期间的平均心率,使其与OSA区分开来.
结论:
- COMISA诱导了特定的夜间ANS功能障碍.
- 需要进一步的HRV研究来了解COMISA对心血管的影响.
- 针对COMISA的有针对性的干预措施可以改善ANS调节和心血管健康.
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