Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Editorial: Immune functions of neuroglia.

Frontiers in immunology·2026
Same author

Aberrant Potassium Handling by Astrocytes and Epileptic Seizures: A Synthetic Update.

Acta physiologica (Oxford, England)·2026
Same author

Mitochondria transfer in neurological disorders: the key role of neuroglia.

Molecular neurodegeneration·2026
Same author

Astrocytes as Histaminergic Gatekeepers of Anxiety: A New Pathway for Emotional Control.

Journal of neurochemistry·2026
Same author

Congratulations, JNC Turns 70!

Journal of neurochemistry·2026
Same author

Author Correction: Curing the brain: in search for new astrocyte-specific therapies.

Experimental & molecular medicine·2026

相关实验视频

Updated: Jun 26, 2026

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
08:27

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

19.6K

获得功能的PPM1D突变减弱了缺血性中风.

Wenyan He1, Yan Li1, Junwan Fan1

  • 1Department of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of innovative Drug and Device Research & Development for Cerebrovascular Diseases, Beijing, China.

Cell death and differentiation
|May 21, 2025
PubMed
概括

蛋白质酸酶依赖1delta (PPM1D) 基因中的遗传突变可以防止缺血性中风. 一种新药,T2755,稳定PPM1D,并显示出治疗中风的希望.

更多相关视频

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research
04:46

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Published on: May 5, 2023

3.5K
Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

1.7K

相关实验视频

Last Updated: Jun 26, 2026

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
08:27

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

19.6K
Author Spotlight: Innovative Techniques and Future Directions in Stroke Research
04:46

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Published on: May 5, 2023

3.5K
Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

1.7K

科学领域:

  • 遗传学 遗传学 是一个
  • 神经学 神经学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 在全球范围内,中风是导致死亡的主要原因,因此需要对其遗传基础和治疗策略进行研究.
  • 识别影响中风病变的遗传因素对于开发有效治疗方法至关重要.

研究的目的:

  • 研究基因异常的作用,特别是PPM1D基因,在缺血性中风的背景下.
  • 探索针对PPM1D进行中风治疗的治疗潜力.

主要方法:

  • 10,241名缺血性中风患者的全基因组测序.
  • 分析PPM1D突变及其与临床表型的关联.
  • 在缺乏Ppm1d的小鼠中试验诱导脑缺血.
  • 脑内皮细胞的空间转录和蛋白质分析.
  • 一个稳定小分子PPM1D的识别和验证 (T2755).

主要成果:

  • 八名具有功能的PPM1D突变的患者表现出改善的临床结果和减少的炎症标志物.
  • 缺乏Ppm1d的小鼠表现出更严重的中风结果,包括更大的病变和神经缺陷.
  • 通过PPARα途径,PPM1D缺陷破坏了内皮平衡和脂肪酸代谢.
  • 小分子T2755稳定了PPM1D,并显著减少了小鼠的缺血性脑损伤.

结论:

  • 在PPM1D中获得功能的突变可以防止缺血性脑损伤.
  • 在缺血性中风期间,PPM1D在维持内皮平衡中起着至关重要的作用.
  • 使用T2755对PPM1D的药理稳定是一种有前途的治疗方法,用于缺血性中风.