在DSS诱导的大肠炎大鼠中,共生性木的抗炎作用和肠道微生物群调节
Atcharaporn Ontawong1, Arthid Thim-Uam2, Sirinat Pengnet1
1Division of Physiology, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
协生菌 (SM) 有效地降低了炎症,并改善了大肠炎的老鼠的肠道健康. 这种功能性食物在治疗炎症性肠病 (IBD) 中表现有前途,需要进一步的临床研究.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 炎症性肠病 (IBD) 病例在2021年升了88.30%,影响了患者的生活质量.
- 协生菌为IBD管理提供了潜在的治疗途径.
- 在大肠炎模型中,共生 (SM) 的抗炎作用和肠道微生物群调节需要进一步探索.
研究的目的:
- 为了研究协生性木 (SM) 在德克斯--硫酸盐 (DSS) 诱导的大肠炎中的抗炎活性,大鼠.
- 在大肠炎模型中分析SM对肠道微生物群组成的影响.
- 评估SM作为潜在的功能性食物治疗大肠炎.
主要方法:
- 通过使用DSS诱导小鼠患有急性结肠炎,并分为七组,包括对照组,DSS,DSS+SM (剂量不同) 和DSS+Sulfazalazine (SUL).
- 治疗方法是每天通过口服输液进行14天的治疗.
- 评估了疾病活动指数 (DAI),体重 (BW),器官巨度,结肠长度,结肠组织形态学和肠道微生物群组成.
主要成果:
- 施用SM显著改善了DAI,BW,肝炎,结肠长度和结肠组织形状学,与SUL相比.
- 微粒治疗降低了IL-6水平,并在结肠中抑制了iNOS和IL-10mRNA的表达.
- SM显著调节了肠道微生物群,增加了Allobaculum的丰富性,并影响了代谢酶类.
结论:
- 协生性木 (SM) 显示出显著的抗炎作用,并改善了DSS诱导的大肠炎大鼠的肠道健康.
- 肠炎可以作为一个有前途的功能性食物疗法.
- 需要进行进一步的临床试验,以验证SM在炎症性肠病中的治疗潜力.
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