NOD1 缺乏会通过自性降解ASK1促进炎症
Yoshitaka Kimura1,2, Miyako Kimura3,4, Noriko Miura5
1Department of Microbiology and Immunology, Teikyo University School of Medicine, Tokyo, Japan. yo.kimura.july@med.teikyo-u.ac.jp.
Communications biology
|May 21, 2025
概括
含有核酸结合寡合化域的蛋白1 (NOD1) 通过促进选择性自来调节炎症. 缺少NOD1会加剧炎症反应,强调其关键的抗炎作用.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 含有核酸结合寡合化域的蛋白1 (NOD1) 是一个关键的模式识别受体,参与检测细菌甘油.
- 众所周知,NOD1信号诱导自,以消除细胞内细菌.
研究的目的:
- 研究NOD1在调节宿主细胞蛋白自的作用及其抗炎作用.
- 阐明NOD1调节炎症反应的机制,特别是在内质网膜 (ER) 应激的背景下.
主要方法:
- 使用Candida albicans水溶性部分 (CAWS) 诱导的冠状动脉炎 (川崎病的模型) 的小鼠模型.
- 在野生型和NOD1缺乏的小鼠中比较疾病表现型和炎症性细胞因子表达.
- 研究了NOD1和细胞灭绝信号调节激酶1 (ASK1) 之间的相互作用及其在自和ER压力中的作用.
主要成果:
- 缺乏NOD1的小鼠在对CAWS的反应中表现出恶化的疾病表型和更高的炎症性细胞因子表达.
- 在NOD1缺乏的骨髓衍生的树突细胞中,CAWS诱导了显著的ER压力.
- NOD1与ASK1直接相互作用,通过ATG16L1促进其选择性自,从而抑制了ER应力依赖的ASK1激活.
结论:
- NOD1通过调解宿主细胞蛋白的选择性自产生关键的抗炎作用,特别准ASK1.1.
- NOD1通过自诱导抑制ER压力依赖的途径,作为过度炎症的负调节剂.
- 这些发现揭示了NOD1介导的免疫调节的新型机制,对于控制炎症疾病至关重要.
相关概念视频
Autophagic Cell Death
2.9K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
2.9K
Autophagy
4.1K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.1K
Delivery Pathways to the Lysosome
6.1K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
6.1K
NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.0K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.0K
Phagocytosis of Apoptotic Cells
3.3K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Normal cells contain receptors that prevent them from being recognized...
3.3K


