Search

Search

这页已由机器翻译。其他页面可能仍然显示为英文。 View in English

首页
...
研究领域生物医学和临床科学医学微生物学医学寄生虫学
用蚊子控制疟疾的Plasmodium点体内查

用蚊子控制疟疾的Plasmodium点体内查

Alexandra S Probst ¹, Douglas G Paton ^1,2, Federico Appetecchia ¹, Selina Bopp ¹, Kelsey L Adams ¹, Tasneem A Rinvee ¹, Sovitj Pou ³, Rolf Winter ³, Esrah W Du ¹, Sabrina Yahiya ⁴, Charles Vidoudez ⁵, Naresh Singh ¹, Janneth Rodrigues ⁶, Pablo Castañeda-Casado ⁶, Chiara Tammaro ⁷, Daisy Chen ⁸, Karla P Godinez-Macias ⁸, Jasmine L Jaramillo ⁹, Giovanna Poce ⁷, Michael J Rubal ⁹, Aaron Nilsen ^3,10, Elizabeth A Winzeler ⁸, Jake Baum ^4,11, Jeremy N Burrows ¹², Michael K Riscoe ^3,10, Dyann F Wirth ^13,14, Flaminia Catteruccia ^15,16

Alexandra S Probst ¹, Douglas G Paton ^1,2, Federico Appetecchia ¹

¹Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
²Department of Infectious Disease, University of Georgia, Athens, GA, USA.
³VA Medical Center, Portland, OR, USA.
⁴Department of Life Sciences, Imperial College London, London, UK.
⁵Harvard Center for Mass Spectrometry, Cambridge, MA, USA.
⁶Global Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
⁷Department of Chemistry and Pharmaceutical Technologies, Sapienza University of Rome, Rome, Italy.
⁸Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
⁹Southwest Research Institute, San Antonio, TX, USA.
¹⁰Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.
¹¹School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
¹²Medicines for Malaria Venture, Geneva, Switzerland.
¹³Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA. dfwirth@hsph.harvard.edu.
¹⁴Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA. dfwirth@hsph.harvard.edu.
¹⁵Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA. fcatter@hsph.harvard.edu.
¹⁶Howard Hughes Medical Institute, Boston, MA, USA. fcatter@hsph.harvard.edu.

⁰Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Nature +

|

2025年五月21日

相关实验视频

These videos have been matched automatically. Contact us if they are not relevant.

Standard Membrane Feeding Assay for the Detection of <em data-lazy-src=

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination

Published on: July 4, 2007

<em data-lazy-src=

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

See all related videos

在PubMed上查看摘要

概括

此摘要是机器生成的。

通过杀死蚊子内的寄生虫来对抗疟疾. 类似内分泌素的昆 (ELQs) 在防止寄生虫的传播方面表现有前途,即使在Anopheles蚊子中具有抗虫剂的特性.

科学领域

医学昆虫学
寄生虫学
药物发现

背景情况

疟疾死亡人数正在因抗虫剂耐药的阿诺菲莱斯蚊子而停滞不前,从而降低了长期使用的抗虫剂处理网的有效性.
直接向寄生虫的蚊子阶段提供了一种克服抗虫剂和预防疟疾传播的策略.

研究的目的

查化合物对蚊子阶段的Plasmodium falciparum寄生虫的活性
开发新型抗寄生素化合物,用于LLIN,以对抗抗虫剂耐药性.

主要方法

针对早期蚊子阶段的寄生虫具有多种作用的81种化合物的体内查.
药物化学优化活性化合物,导致内类类 (ELQs).
在防虫剂耐药蚊子的床网膜中加入和测试ELQ化合物.

主要成果

在81种查的化合物中,有22种抑制了蚊子中肠中的早期寄生虫,防止了感染的发生.
针对Plasmodium falciparum bc1复合体 (CytB) 的优化ELQ化合物在床网膜中表现出强烈的长期活性.
在抗杀虫剂的蚊子中,ELQ的有效性保持不变,耐药寄生虫的蚊子发育阶段受损.

结论

内类类 (ELQ) 显示出在LLIN中整合的显著潜力.
通过向蚊子中的寄生虫,ELQs可以有效地抵消抗虫剂和减少疟疾传播.

相关实验视频

这些视频已自动匹配 Contact us 如果它们不相关

Standard Membrane Feeding Assay for the Detection of <em>Plasmodium falciparum</em> Infection in <em>Anopheles</em> Mosquito Vectors

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination

Published on: July 4, 2007

<em>In Vitro</em> Assay of <em>Plasmodium</em>-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

See all related videos

相关概念视频

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

Share

X
Facebook
LinkedIn
YouTube

ABOUT JoVE

Overview
Leadership
Blog
JoVE Help Center

AUTHORS

Publishing Process
Editorial Board
Scope & Policies
Peer Review
FAQ
Submit

LIBRARIANS

Testimonials
Subscriptions
Access
Resources
Library Advisory Board
FAQ

RESEARCH

JoVE Journal
Methods Collections
JoVE Encyclopedia of Experiments
Archive

EDUCATION

JoVE Core
JoVE Business
JoVE Science Education
JoVE Lab Manual
Faculty Resource Center
Faculty Site

Terms & Conditions of Use
Privacy Policy
Policies