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Updated: May 23, 2025

Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae
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通过人类SLC35B1将ATP逐步转移到内细胞网

Ashutosh Gulati1, Do-Hwan Ahn1, Albert Suades1

  • 1Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Stockholm, Sweden.

Nature
|May 21, 2025
PubMed
概括

细胞内膜网 (ER) 通过SLC35B1输送器导入ATP,而不是核酸糖. 化电磁结构显示SLC35B1

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A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
Targeting proteins to the ER
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Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
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Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
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