50岁以下美国人的炎症生物标志物和胆结石之间的关联
Shuqin Cheng1, Yaping Zhang2,3, Lu Jiang1
1First Central Hospital of Tianjin Medical University, Tianjin, 300070, China.
BMC gastroenterology
|May 21, 2025
概括
像中性粒细胞与淋巴细胞比率 (NLR) 和全身免疫炎症指数 (SII) 这样的炎症生物标志物与50岁以下成年人的胆结石风险有线相关. 系统性炎症反应指数 (SIRI) 显示了与胆结石发育的反向"U"关系.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 胆结石是一种普遍的健康问题,特别是在年轻人中.
- 炎症生物标志物可能在胆结石形成中发挥作用.
- 了解这些联系可以为预防策略提供信息.
研究的目的:
- 调查50岁以下美国成年人关键炎症生物标志物和胆结石之间的关联.
- 探索这些标记物和胆结石患病率之间的线性和非线性关系.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2017-2020年).
- 采用加权多重逻辑回归和限制立方线 (RCS) 模型.
- 分析了3,295名年龄在50岁以下的人的数据.
主要成果:
- 增加的中性粒细胞与淋巴细胞比率 (NLR),全身免疫炎症指数 (SII) 和全身炎症反应指数 (SIRI) 与增加胆结石风险有关.
- ln-NLR (OR=1.68) 和 ln-SII (OR=1.79) 显示出一个显著的正线性关联.
- ln-SIRI表明,与胆结石有显著的反向"U"形非线性关联.
结论:
- 中性粒细胞与淋巴细胞的比率 (NLR) 和全身免疫炎症指数 (SII) 与更高的胆结石风险有线相关.
- 系统性炎症反应指数 (SIRI) 与胆结石风险有非线性,反向的"U"关系.
- 这些发现强调了系统性炎症在年轻人胆结石形成中的作用.
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