昼夜综合征与MASLD风险之间的关联:来自大型横截面研究的证据
Jihan Sun1,2, Shuqi Mao3, Caide Lu4
1Department of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, 315041, Zhejiang, China.
BMC gastroenterology
|May 21, 2025
概括
循环节综合征 (CircS) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险增加了四倍. 识别CircS可能有助于检测患MASLD风险较高的个体.
科学领域:
- 代谢健康 代谢健康
- 时间生物学 时间生物学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种广泛的肝病,与代谢综合征和昼夜节律障碍有关.
- 循环节综合征 (CircS),以代谢和循环节失调为特征,是代谢障碍的新兴风险因素.
研究的目的:
- 调查循环节综合症 (CircS) 和 MASLD 之间的关联.
- 评估CircS在识别患MASLD风险增加的个人的潜力.
主要方法:
- 分析了2017-2018年NHANES周期的2,288名参与者.
- 权重后勤回归和限制立方线分析,以确定CircS和MASLD之间的关联和剂量反应关系.
- 亚组分析以确定潜在的效果修饰剂.
主要成果:
- 在CircS和MASLD之间发现了显著的关联.
- 患有CircS的人患MASLD的几率是4.123倍 (调整后OR=4.123,95%CI:2.489-6.832,P=0.001).
- 一个线性趋势表明,更高的CircS得分与更高的MASLD风险相关,在人口亚组中一致.
结论:
- 循环节综合征 (CircS) 与 MASLD 有显著的关联.
- CircS可能有助于早期风险识别和针对MASLD的有针对性的干预.
- 在临床实施之前,需要在前性研究中进一步验证.
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