Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

MicroRNA-183 regulates lipopolysaccharide-induced oxidative stress of hippocampal neurons by targeting the fibronectin 1 gene.

Neuroscience letters·2020
Same author

Combination of inflammatory score/liver function and AFP improves the diagnostic accuracy of HBV-related hepatocellular carcinoma.

Cancer medicine·2020
Same author

Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study.

World journal of gastroenterology·2020
Same author

The Accumulation and Metabolism Characteristics of Rare Earth Elements in Sprague-Dawley Rats.

International journal of environmental research and public health·2020
Same author

Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study.

Hepatology international·2020
Same author

Long-term outcomes of multimodality management for parasagittal meningiomas.

Journal of neuro-oncology·2020

相关实验视频

Updated: May 8, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

408.7K

scHiCSRS:一种与高斯混合模型的自我表示光滑方法,用于赋值单细胞Hi-C数据.

Qing Xie1, Wang Meng2, Shili Lin3,4

  • 1Interdisciplinary Ph.D. Program in Biostatistics, The Ohio State University, Columbus, OH, 43210, USA.

BMC bioinformatics
|May 21, 2025
PubMed
概括

单细胞Hi-C (scHi-C) 数据由于结构零和脱落而稀疏. 我们的scHiCSRS方法区分了这些零点,改善了数据质量,以便更好地进行细胞聚类和细胞对细胞变异性的分析.

关键词:
学的人 学的人邻里地区 邻里地区采样的零点是采样的零点.稀缺性 是一种稀缺性.结构上的零点.

更多相关视频

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

1.9K
Author Spotlight: Vascular Tissue Dissociation and Exploring Single-Cell Subclusters for Targeted Therapy
04:21

Author Spotlight: Vascular Tissue Dissociation and Exploring Single-Cell Subclusters for Targeted Therapy

Published on: January 19, 2024

2.7K

相关实验视频

Last Updated: May 8, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

408.7K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

1.9K
Author Spotlight: Vascular Tissue Dissociation and Exploring Single-Cell Subclusters for Targeted Therapy
04:21

Author Spotlight: Vascular Tissue Dissociation and Exploring Single-Cell Subclusters for Targeted Therapy

Published on: January 19, 2024

2.7K

科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 分子生物学分子生物学

背景情况:

  • 单细胞Hi-C (scHi-C) 能够研究细胞间的变异性.
  • 由于结构和采样零值 (dropouts),scHi-C数据稀疏,阻碍了下游分析.
  • 区分零类型对于准确解释scHi-C数据至关重要.

研究的目的:

  • 开发一种方法来区分结构零和scHi-C数据中的脱落.
  • 提高scHi-C数据的质量,以加强下游分析.
  • 为了促进更准确的细胞聚类和细胞对细胞变异的理解.

主要方法:

  • 建议 scHiCSRS,一种自我表达平滑方法.
  • 利用高斯混合模型来识别结构零.
  • 整合了来自类似单个单元格的空间依赖和信息.

主要成果:

  • scHiCSRS有效地识别了具有高灵敏度的结构零.
  • 在采样零值中实现了脱落值的准确归算.
  • 与现有方法相比,scHiCSRS改进的数据产生了更准确的细胞聚类.

结论:

  • scHiCSRS是一个有价值的工具,用于识别结构性零点,并归纳scHi-C数据中的掉落.
  • 改进的scHi-C数据增强了下游分析,特别是细胞亚型聚类.
  • 这种方法有助于通过提高数据质量来理解细胞对细胞的变异.