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周周血管脂肪组织功能障碍有助于胸前大动脉动脉瘤的发展

Zhenguo Wang¹, Wenjuan Mu¹, Ruiyan Xu^1,2

¹Department of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA.

Cardiovascular diabetology

|May 21, 2025

概括

周周血管脂肪组织 (PVAT) 色对于预防胸前大动脉动脉瘤 (TAA) 至关重要. PVAT功能障碍加剧TAA,建议针对TAA预防PVAT色的治疗策略.

科学领域:

血管生物学血管生物学
脂肪组织生物学脂肪组织生物学
心血管疾病的发病因子心血管疾病的发病因子

背景情况:

胸前动脉动脉瘤 (TAA) 是一种危及生命的疾病,分子机制尚不清楚.
周血管脂肪组织 (PVAT) 在血管恒温中发挥作用,健康的PVAT类似于棕色脂肪组织 (BAT).
以白色为特征的PVAT功能障碍与血管疾病有关,但其在TAA中的因果作用尚不清楚.

研究的目的:

研究PPARg和PRDM16在PVAT中的作用及其对TAA发展的影响.
阐明将PVAT功能障碍与TAA病变发生联系起来的分子机制.

主要方法:

分析TAA患者的PVAT样本.
针对Pparg (Pparg^BAKO) 和Prdm16 (Prdm16^BAKO) 的棕色脂肪细胞特异性淘汰赛小鼠模型的生成.
在小鼠中使用猪胰腺弹性酶 (PPE) 诱导TAA,并通过组织学染色进行评估;使用光酶记者测定和ChIP-qPCR识别的PRDM16基因.

主要成果:

TAA患者的PVAT显示棕色变化减少,白色标志物增加.
在Pparg^BAKO和Prdm16^BAKO小鼠中,PVAT发育受损,TAA形成恶化.
迪科林被确定为PRDM16的基因,在功能障碍的PVAT和TAA患者的血中表达增加.

结论:

在PVAT中保持棕色的特征对于对TAA的保护至关重要.
PVAT功能障碍是TAA发展的一个因素.
诱导PVAT色是一种潜在的治疗策略,可以预防TAA.

关键词:

在 Decorin Decorin 中使用.在PPARg中,PPARg是PPARg.在PRDM16中,我们可以看到:周周血管脂肪组织胸前大动脉动脉瘤胸前大动脉动脉瘤

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