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The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
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相关实验视频

Updated: May 23, 2025

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
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周周血管脂肪组织功能障碍有助于胸前大动脉动脉瘤的发展.

Zhenguo Wang1, Wenjuan Mu1, Ruiyan Xu1,2

  • 1Department of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA.

Cardiovascular diabetology
|May 21, 2025
PubMed
概括

周周血管脂肪组织 (PVAT) 色对于预防胸前大动脉动脉瘤 (TAA) 至关重要. PVAT功能障碍加剧TAA,建议针对TAA预防PVAT色的治疗策略.

关键词:
在 Decorin Decorin 中使用.在PPARg中,PPARg是PPARg.在PRDM16中,我们可以看到:周周血管脂肪组织胸前大动脉动脉瘤 胸前大动脉动脉瘤

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科学领域:

  • 血管生物学 血管生物学
  • 脂肪组织生物学 脂肪组织生物学
  • 心血管疾病的发病因子 心血管疾病的发病因子

背景情况:

  • 胸前动脉动脉瘤 (TAA) 是一种危及生命的疾病,分子机制尚不清楚.
  • 周血管脂肪组织 (PVAT) 在血管恒温中发挥作用,健康的PVAT类似于棕色脂肪组织 (BAT).
  • 以白色为特征的PVAT功能障碍与血管疾病有关,但其在TAA中的因果作用尚不清楚.

研究的目的:

  • 研究PPARg和PRDM16在PVAT中的作用及其对TAA发展的影响.
  • 阐明将PVAT功能障碍与TAA病变发生联系起来的分子机制.

主要方法:

  • 分析TAA患者的PVAT样本.
  • 针对Pparg (PpargBAKO) 和Prdm16 (Prdm16BAKO) 的棕色脂肪细胞特异性淘汰赛小鼠模型的生成.
  • 在小鼠中使用猪胰腺弹性酶 (PPE) 诱导TAA,并通过组织学染色进行评估;使用光酶记者测定和ChIP-qPCR识别的PRDM16基因.

主要成果:

  • TAA患者的PVAT显示棕色变化减少,白色标志物增加.
  • 在PpargBAKO和Prdm16BAKO小鼠中,PVAT发育受损,TAA形成恶化.
  • 迪科林被确定为PRDM16的基因,在功能障碍的PVAT和TAA患者的血中表达增加.

结论:

  • 在PVAT中保持棕色的特征对于对TAA的保护至关重要.
  • PVAT功能障碍是TAA发展的一个因素.
  • 诱导PVAT色是一种潜在的治疗策略,可以预防TAA.