多药学和药物基因组学在高急性自闭症谱系障碍的行为健康护理中:一项回顾性研究
Sheldon R Garrison1, Sophie A Schweinert2, Matthew W Boyer3
1Rogers Behavioral Health, Research Center, 34700 Valley Road, Oconomowoc, WI, 53066, USA. sheldon.garrison@rogersbh.org.
Child and adolescent psychiatry and mental health
|May 21, 2025
概括
患有自闭症谱系障碍 (ASD) 的儿童的药物基因组 (PGx) 测试没有减少多药或改善生活质量. 虽然PGx测试影响了药物处方,但PGx和通常治疗组之间的整体结果仍然相似.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 自闭症谱系障碍 (ASD) 通常涉及同时出现的抑郁和焦虑,导致心理药物药物多药.
- 药物基因组 (PGx) 测试可能为优化药物选择和减少多药在这个人群中的策略提供了一个策略.
- 这项研究调查了PGx测试对患有自闭症的儿童和青少年的影响.
研究的目的:
- 评估PGx测试在减少ASD儿童和青少年心理药物多药物的有效性.
- 评估PGx测试对ASD儿科患者生活质量和症状严重性的影响.
- 为了比较接受PGx测试和接受通常治疗 (TAU) 的患者之间的结果.
主要方法:
- 在2017年1月至2023年5月期间,对99名自闭症患者进行了回顾性电子健康记录 (EHR) 审查.
- 接受PGx测试的患者和接受TAU的患者之间的结果比较.
- 主要结局包括多药房率和生活质量 (PQ-LES-Q);次要结局评估症状严重程度和药物使用.
主要成果:
- 在入院时,93%的自闭症患者正在服用精神药物,超过一半的人有潜在的基因药物相互作用.
- PGx测试导致了处方药的减少,这些药物具有潜在的基因药物相互作用.
- 在多药,生活质量或症状严重程度方面,PGx和TAU组之间没有发现显著差异.
结论:
- 将PGx测试纳入ASD儿童和青少年的医疗工作中,并没有显著改善多药或生活质量结果.
- 虽然PGx测试影响了药物处方模式,特别是根据药物一致性进行分层时,整体治疗组的结果相似.
- 可能需要进一步的研究来确定特定的子组或临床情景,其中PGx测试在ASD管理中显示出明显的好处.
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