糖尿病患者的心血管风险概况:SCORE2-糖尿病可靠吗?
Sabrina Scilletta1, Maurizio Di Marco1, Nicoletta Miano1
1Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi Hospital, University of Catania, Via Palermo, 636, 95122, Catania, Italy.
SCORE2-糖尿病模型有效地识别了2型糖尿病患者的早期血管损伤,包括动脉硬和动脉样硬化. 这种心血管风险评估工具对于检测临床前损伤的标准SCORE2模型更为优越.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 血管医学 血管医学
背景情况:
- 患有2型糖尿病 (T2D) 的人面临心血管疾病 (CVD) 的风险显著增加.
- 对心血管风险的早期评估对于管理T2D患者至关重要.
- 欧洲心脏病学会开发了SCORE2-糖尿病模型,用于在40岁以上的T2D患者中进行10年心脏病风险估计.
研究的目的:
- 评估SCORE2-糖尿病分层的心血管风险与早期血管损伤之间的关联.
- 通过动脉硬度 (脉冲波速度 - PWV),内心介质厚度 (IMT) 和动脉动脉样硬化来评估早期的心血管损伤.
- 检查SCORE2和SCORE2-糖尿病风险分层之间的一致性,以及它们与血管损伤的一致性.
主要方法:
- 在179名T2D患者 (40-69岁) 中评估PWV,IMT和动脉样硬化.
- 参与者被分类为SCORE2-糖尿病风险组:低,中等,高和非常高.
- 包括一组有动脉样硬化心血管疾病 (ASCVD) 或严重目标器官损伤 (TOD) 病史的患者.
主要成果:
- 在SCORE2-糖尿病风险组中,PWV和IMT显示了显著的逐步增加.
- 非常高风险和ASCVD/TOD组表现出较高的冠状动脉样硬化患病率.
- 与SCORE2.2相比,SCORE2-糖尿病显示出与Score2.2相比,对动脉动脉样硬化和高PWV的预测性能优越.
结论:
- 增加SCORE2-糖尿病风险分层与PWV,IMT和大脑动脉动脉样硬化的更高患病率相关.
- SCORE2-糖尿病是一个可靠的工具,用于识别T2D患者在没有确定的ASCVD或TOD的情况下的临床前血管损伤.
- 该模型与标准SCORE2模型相比,可以更好地识别血管损伤.
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