挑战"牛皮皮肤病变发生在关节炎之前"的教条
Hannah Y Gantz1, Robin C Yi1, Ainsley J Ruley1
1Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
International journal of dermatology
|May 22, 2025
概括
牛皮关节炎 (PsA) 通常出现在可见牛皮皮肤病变之前. 这项研究发现,在牛皮之前的关节炎或其他皮肤疾病,如粉红疹和湿疹是常见的,这表明PsA可能被低诊断.
科学领域:
- 类风湿病学 类风湿病学
- 皮肤病学 皮肤病学
- 临床医学 临床医学
背景情况:
- 牛皮关节炎 (PsA) 通常是在牛皮皮肤病变出现后被诊断出来的.
- 当皮肤表现出现之前,PsA可能被低诊断.
- 这项研究调查了前期牛皮和其他皮肤病的关节炎的流行率.
研究的目的:
- 为了测试牛皮关节炎 (PsA) 通常发生在牛皮之前的假设.
- 为了确定PsA是否经常被误诊为其他形式的关节炎,当皮肤病变不存在时.
- 评估关节炎的发病率,先诊断出牛皮,粉红和亚托邦性皮肤炎.
主要方法:
- 一个单一的三级保健中心 (2023) 电子健康记录的回顾性图表审查.
- 纳入标准:患有关节炎的患者在牛皮,亚托皮性皮肤炎或粉红病之前被诊断为牛皮.
- 国际疾病分类第十次修订 (ICD-10) 代码用于诊断查.
主要成果:
- 在5195名阿托皮性皮炎患者,1672名牛皮患者和2780名粉红患者中,436人患有先前的关节炎.
- 在239名患者 (14.3%) 之前的关节炎是牛皮,在189名患者 (6.8%) 之前是,在126名患者 (2.4%) 之前是湿疹.
- 在这些组中,先前关节炎的患病率具有统计学意义 (p < 0.0001).
结论:
- 关节炎症状经常发生在牛皮皮肤病变发生之前.
- 牛皮的皮肤病变不是牛皮关节炎诊断的先决条件.
- 在皮肤表现之前出现关节炎的患者中,PsA可能被低诊断.
相关概念视频
Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
T Cell Types and Functions
740
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
740
Skin Cancer
3.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.0K
Inflammation
52.1K
Overview
52.1K
The JAK-STAT Signaling Pathway
8.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.6K


