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在非肌肉侵入性膀癌的当代结果:一个大型的欧洲多中心研究
Mattia Longoni1,2,3, Pietro Scilipoti1,2, Mario De Angelis1,2
1Department of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.
BJU international
|May 22, 2025
概括
高风险的非肌肉侵入性膀癌 (NMIBC) 显著增加了复发和进展的风险. 完成适当的静脉灌注疗程对于改善NMIBC患者的瘤结果至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 目前关于非肌肉侵入性膀癌 (NMIBC) 瘤结局的数据有限.
- 关于NMIBC复发和进展的真实数据对于治疗优化至关重要.
研究的目的:
- 为了确定NMIBC复发和进展的真实速度.
- 分析基于欧洲泌尿病学协会风险分层的瘤结果.
- 评估内灌注课程对NMIBC结果的影响.
主要方法:
- 1918名来自六个欧洲中心的NMIBC患者 (2015-2022) 的回顾性分析.
- 根据EAU 2021标准分为低,中,高和非常高风险类别的分层.
- 使用竞争性风险回归分析的5年复发率和进展率,以及对静脉内灌注的灵敏度分析.
主要成果:
- 五年高度复发率:7.2% (LR),17.3% (IR),26.7% (HR),30.9% (VHR) 在5年高度复发率:7.2% (LR),17.3% (IR),26.7% (HR),30.9% (VHR) 在5年高度复发率:
- 五年进展率:3.9% (LR),5.2% (IR),13.6% (HR),31.6% (VHR) 在5年时间内.
- 适当的静脉灌注疗程 (24.3%的治疗患者) 显著减少了HG复发 (HR 0.3) 和进展 (HR 0.2).
结论:
- 高风险和非常高风险的NMIBC患者面临高度复发和进展的大幅增加风险.
- 在HR/VHR NMIBC中,需要量身定制的治疗策略.
- 坚持适当的静脉内灌注课程对于优化NMIBC瘤结果至关重要.
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