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关于 HSIL 的自然历史的分子洞察

Aude Jary^1,2, Ramon P van der Zee^1,2,3, Vita Jongen^4,5,6

¹Pathology, Amsterdam UMC Location VU University, Amsterdam, The Netherlands.

Journal of medical virology

|May 22, 2025

概括

低度和高度状病变 (LSIL;HSIL) 与人类乳头瘤病毒 (HPV) 有关. 分子分析显示HSIL的DNA甲基化增加和拷贝数异常,表明从LSIL或其他致癌途径的进展.

科学领域:

在瘤学瘤学.
病毒学病毒学
分子生物学分子生物学

背景情况:

部平细胞癌经常与人类乳头瘤病毒 (HPV) 感染有关.
从低级状内皮病变 (LSIL) 到高级状内皮病变 (HSIL) 的进展是癌发生的一个关键步骤.

研究的目的:

为了对配对的LSIL和HSIL病变进行分子比较.
评估从LSIL到HSIL的关系和潜在进展.
调查HPV类型,DNA甲基化和副本数异常在部病变发展中的作用.

主要方法:

从22名男性患者对联LSIL和HSIL活检的纵向采集.
综合分子分析包括HPV类型 (和HPV16变体),细胞DNA甲基化水平和复制数异常 (CNA).
组织病理学审查活检以将病变分类为LSIL或HSIL.

主要成果:

与LSIL相比,HSIL中的DNA甲基化水平和CNA都显著增加.
在22名患者中的15名患者中,在基线时的LSIL与随访时的HSIL有关.
一个HSIL子集显示HPV类型的持久性与增加的分子变化,而另一个子集显示HPV类型的交换机,表明不同的途径.

结论:

一些LSIL病变可能会发展为HSIL,其特征是HPV类型的持久性和增加的分子变化.
在LSIL之后的HSIL中发生HPV型切换的发生表明癌发生的另一种途径.
像DNA甲基化和CNA这样的分子标记在了解门病变的进展方面至关重要.

关键词:

一个 AIN1 一个 AIN1 AIN2 AIN2 AIN2 AIN2 AIN2 AIN2 AIN2 AIN2 AIN2 AIN2 AIN2 AIN2 AIN2 AIN3 AIN3 AIN3 AIN3 AIN3 AIN3 AIN3 AIN3 AIN3 AIN3 AIN3 在HSIL的基础上,HSIL LSIL LSIL 在线阅读部损伤进展的进展复制号误差复制号误差甲基化标志物的甲基化标志物

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