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和多醇基物质 (PFAS):在暴露的主要部位的免疫毒性

Emma Arnesdotter¹, Charlotte B A Stoffels¹, Wiebke Alker²

¹Environmental Sustainability Assessment and Circularity (SUSTAIN) Unit, Luxembourg Institute of Science and Technology, Esch-sur-Alzette, Luxembourg.

Critical reviews in toxicology

|May 22, 2025

概括

暴露于和多基物质 (PFAS) 可能会损害免疫反应,特别是疫苗抗体的产生. 本次审查强调了关于PFAS在肺,肠道和皮肤中的免疫调节作用的人类数据,强调了需要更多研究的需要.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
免疫学免疫学免疫学

背景情况:

和多基基物质 (PFAS) 是许多产品中存在的持久合成化学物质,导致广泛的环境污染和人类暴露.
perfluoroalkyl酸 (PFAA),PFAS的一个子集,通常通过饮食,饮用水,尘埃和皮肤接触被摄入.
欧洲食品安全局确定疫苗抗体反应受损是PFAS风险评估的关键影响.

研究的目的:

审查 perfluoroalkyl 酸 (PFAA) 对主要暴露部位的免疫调节作用:肺部,肠道和皮肤.
用人类流行病学数据调查这些影响.
评估PFAA体外毒性测试的现状,并确定研究中的关键缺口.

主要方法:

对PFAS暴露和免疫相关结果的人类流行病学研究的审查.
对PFAA对肺部,肠道和皮肤的影响的数据的检查.
对体外毒性测试方法和结果的分析.

主要成果:

人类研究将PFAS暴露与喘,过敏和炎症性肠道疾病等与免疫相关的问题联系起来.
有证据表明,PFAA可以调节暴露的关键部位的免疫反应.
审查了PFAA的体外毒性测试,突出了需要改进和进一步调查的领域.

结论:

perfluoroalkyl 酸 (PFAA) 对免疫功能构成潜在风险,对公共健康有重大影响.
进一步以人为基础的研究对于充分了解PFAA的免疫影响至关重要.
需要改进的体外方法来支持对 PFAS 的人类健康风险评估.

关键词:

在PFAS中,我们可以使用PFAS.免疫毒性免疫毒性我们的肠道是肠道.在体外 (in vitro) 的情况下.肺肺肺肺肺肺肺肺肺通过和多基基物质.皮肤皮肤皮肤

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