来自中国一个大城市的尘埃落下的微塑料通过PI3K/Akt/mTOR路径抑制自
Yajing Ma1, Jinjin Yu1, Jian Sun2
1School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Environment & health (Washington, D.C.)
|May 22, 2025
概括
城市灰尘中的微塑料会通过抑制自和诱导亡,引发细胞毒性,炎症和氧化应激. 清除微塑料扭转了这些有害健康影响,突出了吸入风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 微塑料 (MP) 污染在城市环境中对健康构成重大风险.
- 灰尘降落 (DF) 是城市MP暴露的主要途径.
研究的目的:
- 为了调查在中国西安市尘埃落下的国会议员的存在和毒性.
- 阐明MP吸入引起的健康风险背后的细胞机制.
主要方法:
- 热解气色谱-质谱法被用来识别9种类型的MPs/微 (MRs) 在DF样本中.
- 细胞毒性,炎症和氧化应激测试是在暴露于DF和MP样本的Raw264.7细胞上进行的.
- 分析了与自和亡相关的蛋白质表达水平.
主要成果:
- 议员占原来的DF (DF-O) 的51.20%.
- 与残留样本 (DF-S) 相比,DF-O和MP样本显示出明显更高的细胞毒性,炎症和氧化应激.
- MPs抑制了自性 (调低LC3B,p-PI3K,p-Akt,p-mTOR;调高p62) 和诱导细胞灭绝 (增加Bax/Bcl-2和Cleaved Caspase-3/Caspase-3的比率).
结论:
- 在尘埃落下的大气MP抑制了自并通过PI3K/Akt/mTOR通路诱导了亡.
- 这些发现提供了有关吸入国会议员城市尘埃的健康风险的关键见解.
- 降低尘埃落下的MP水平可以减轻相关的毒理效应.
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