对一种新型的人类腺病毒类型HAdV-D116的鉴定和鉴定
Menglan Zhou1,2, Wenjing Chen3, Dong Zhang1,2
1Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Frontiers in microbiology
|May 22, 2025
概括
一种新型的人类腺病毒,HAdV-D116,在脑脊液中被发现,来自脑炎患者. 这一发现突显了腺病毒可能导致罕见的中枢神经系统感染的可能性.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 人类腺病毒 (HAdV) 通常会导致呼吸道和胃肠道疾病.
- 中枢神经系统 (CNS) 感染HAdVs是罕见的,但可能是严重的.
研究的目的:
- 在免疫功能低下的患者中识别脑炎的致病原体.
- 在脑脊液中发现的一种新型HAdV的特征.
主要方法:
- 大脑脊髓液的元基因组下一代测序 (mNGS).
- 样本捕获丰富测序和PCR验证.
- 全基因组测序和遗传学分析.
主要成果:
- 一种新型的HAdV,被指定为HAdV-D116,在X链接的AGAMMAGLOBULINEMIA的脑炎患者的脑脊液中被发现.
- HAdV-D116属于人类乳腺病毒D物种,并且在E3基因中具有独特的删除,创建了一个新的开放阅读框架.
- 基因组分析表明,HAdV-D116是一种重组菌株,可能使用酸作为受体.
结论:
- HAdV-D116的独特基因组特征可能有助于其中枢神经系统感染性,特别是在免疫受损的个体中.
- 这一发现扩大了人类腺病毒已知的热带性.
- 强调在无法解释的中枢神经系统感染中考虑新型HAdV菌株的重要性.
更多相关视频
13:17Cloning and Large-Scale Production of High-Capacity Adenoviral Vectors Based on the Human Adenovirus Type 5
Published on: January 28, 2016
14.3K
10:22Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
Published on: November 12, 2015
8.7K
相关概念视频
Human Virome
The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Herpes
Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Genital Herpes
Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
