盐美国 (Solanum americanum) 的水性提取物 Mill. 通过调节肠道神经系统和肠道微生态系统来缓解功能性便秘
Xiaoyu Gao1,2,3, Yanan Li2, Yifan Hu1,3
1Yunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming, China.
Frontiers in nutrition
|May 22, 2025
概括
索拉南美 (Solanum americanum) 水性提取物 (SAAE) 通过改善肠道通道和减少炎症,有效治疗小鼠的便秘. SAAE调节肠道神经系统和肠道微生物群,显示出新的药产品的潜力.
科学领域:
- 药理学和传统医学的医学.
- 胃肠病学 胃肠病学
- 微生物组学 微生物组学
背景情况:
- 索拉美洲 米尔. (SA) 传统上用于消化健康.
- 没有科学研究研究了它对便秘的松性质.
- 功能性便秘 (FC) 是一种常见的胃肠道疾病.
研究的目的:
- 为了评估Solanum americanum水性提取物 (SAAE) 的药活性.
- 为了研究SAAE的潜在机制在洛佩拉胺诱导的便秘小鼠模型中.
主要方法:
- 洛佩拉胺诱导的功能性便秘小鼠模型.
- 不同剂量的SAAE (300,600,900 mg/kg·bw) 的管理.
- 评估排便,胃肠道过渡,结肠转录组,血清/结肠神经递质,细胞亡,神经元标记物,肠道炎症,屏障功能和肠道微生物群.
主要成果:
- 在FC小鼠中,SAAE显著改善了排便和胃肠道过渡,在600 mg/kg·bw.
- SAAE调节结肠转录基因组,特别是神经活性联体受体相互作用和TNF受体1型信号传递.
- SAAE缓解了肠道炎症,改善了肠道屏障的完整性,恢复了肠道微生物群的平衡,增加了有益的种群.
结论:
- 通过调节肠道神经系统和神经递质水平,SAAE显示出显著的松作用.
- 通过减少炎症,修复肠道屏障和重新平衡肠道微生物群,SAAE促进肠道健康.
- SAAE显示出作为功能性便秘的治疗剂的潜力,支持Solanum americanum的传统使用.
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