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以计算机断层扫描为指导的穿皮活检用于诊断肺结节:一个前性的多中心观察性研究

Yun Liu¹, Ling Zhao², Hua-Long Yu³

¹Department of Cancer Center, Daping Hospital, Army Medical University, Chongqing, China.

Journal of thoracic disease

|May 22, 2025

概括

计算机断层扫描 (CT) 引导的皮肤透析活检 (CTPB) 准确诊断肺结节,准确率为95.10%. 结节类型和活检技术等因素会影响结果,而常见的并发症不会显著影响诊断的准确性.

科学领域:

肺部病理学肺部病理学
放射学放射学是一门学科.
胸部外科手术胸部外科手术

背景情况:

肺结节是常见的发现,需要准确的诊断来管理患者.
计算机断层扫描 (CT) 引导的皮间活检 (CTPB) 是诊断肺结节的可访问方法.
在现实世界中,CTPB的诊断准确性需要进一步评估.

研究的目的:

评估CT指导皮肤透析活检 (CTPB) 对肺结节的诊断准确性.
确定影响CTPB准确性的因素.
评估CTPB相关并发症的发生率.

主要方法:

预计将在中国10个医疗中心招收591名患者.
主要结局:活检病理和最终临床诊断之间的一致性.
二次结局:与活检相关的并发症发生率;使用后勤回归和ROC曲线分析的数据.

主要成果:

CTPB的整体诊断准确率为95.10% (特异性为100%,灵敏度为92.79%).
固体结节,特定的亚固体结节特征,半自动针和切口数量显著影响了准确性 (AUC:0.812).
常见的并发症包括肺胸 (13%) 和肺出血 (27.1%),这些并没有影响诊断的准确性;其他并发症很少见.

结论:

在现实临床实践中,CTPB在肺结节的诊断准确度很高.
诸如结节特征和活检技术等因素对于优化诊断产量至关重要.
降低肺胸炎和肺出血等并发症的发生率对于更广泛的CTPB应用至关重要.

关键词:

计算机断层扫描指导 (CT指导)活组织活检肺部结节肺部结节

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