大学生结核病预防治疗完成的预测因素:中国的一项高坚持性研究
Cuixiao Liu1, Rui Jing1, Shasha Li1
1Institute for Tuberculosis Control, Jinan Center for Disease Control and Prevention, Jinan, People's Republic of China.
Infection and drug resistance
|May 22, 2025
概括
在患有潜伏性结核感染 (LTBI) 的大学生中观察到结核预防治疗 (TPT) 的高完成率. 诸如不良反应,学生类型,教育和收入等因素影响了TPT的坚持,指导了未来的干预.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 临床试验管理 临床试验管理
背景情况:
- 潜在结核病感染 (LTBI) 需要预防性治疗,以减少重新激活的风险.
- 大学生代表了LTBI管理的独特人群,因为他们共享生活环境和传播潜力.
- 了解影响治疗完成的因素对于在这个人群中有效控制LTBI至关重要.
研究的目的:
- 调查和评估与完成结核病预防治疗 (TPT) 相关的因素,在被诊断患有潜在结核病感染 (LTBI) 的大学生中.
主要方法:
- 在399名LTBI大学生中进行了横截面调查,这些学生在中国山东省启动了TPT.
- 确定了TPT完成率.
- 使用多变量逻辑回归分析来评估与TPT完成相关的因素.
主要成果:
- 观察到一个高的TPT完成率为91.2% (364/399).
- 与医学学生相比,非医学学生完成TPT的可能性较低.
- 较高的家庭收入和教育水平与较低的TPT完成率有关.
- 缺少不良反应显著增加了TPT完成的可能性.
结论:
- 标准化药物管理对于LTBI的大学生成功完成TPT至关重要.
- 建议针对个体 (学生类型,教育,不良事件) 和家庭特征 (收入) 进行量身定制的干预措施,以改善TPT的坚持.
- 通过E值分析表明对未测量的混因子的稳定性,支持确定因素的可靠性.
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