[68Ga]Ga-FAPI-04 PET吸收参数在注射后15分钟和60分钟的可重复性
Hongyu Meng1, Guixia Pan2, Ye Peng2
1Department of Radiology, Shanghai Fourth People's Hospital Affiliated to Tongji University, School of Medicine Shanghai, China.
概括
早期15分钟的-68标记纤维细胞激活蛋白抑制剂 (68Ga-FAPI-04) PET扫描显示与60分钟扫描的高相关性. 这表明,在各种瘤中对SUVmax和SUVmean进行定量分析,可以进行15分钟的成像.
科学领域:
- 核医学就是核医学.
- 瘤成像学成像学
- 放射化学 放射化学是指辐射化学.
背景情况:
- 加-68标记为纤维细胞激活蛋白抑制剂 (68Ga-FAPI-04) PET成像允许在注射后不久可视化瘤.
- 对68Ga-FAPI-04 PET进行定量分析的最佳成像时间点尚未完全阐明.
- 了解定量指标的时间变化对于准确的瘤评估至关重要.
研究的目的:
- 调查68Ga-FAPI-04注射后15分钟和60分钟在各种瘤患者中吸收的定量PET参数之间的相关性.
- 评估早期 (15分钟) 68Ga-FAPI-04 PET成像用于定量瘤分析的可复制性和临床可行性.
- 为了确定特定的定量指标是否可以在两个时间点之间互换使用.
主要方法:
- 对30名接受68Ga-FAPI-04 PET/CT扫描的癌症患者进行了回顾性分析.
- 在注射后15分钟和60分钟获得图像.
- 定量分析包括SUVmax,SUVmean,SUVpeak,瘤与肝脏的比率 (TLR) 和瘤吸收量 (UTV).
- 统计分析涉及斯皮尔曼等级相关性和布兰德-阿尔特曼情节.
主要成果:
- 所有的定量指标 (SUVmax,SUVmean,SUVpeak,UTV) 显示从15分钟下降到60分钟.
- 在SUVmax,SUVmean,SUVpeak,TLR和UTV的15分钟和60分钟定量值之间观察到高相关性 (r > 0.94).
- SUVmax和SUVmean在15到60分钟之间显示出临床上可接受的可重现性,Bland-Altman协议限制在±30%以内.
- SUVpeak,TLR和UTV显示了更广泛的协议范围,表明它们在时间点之间不能互换.
结论:
- 15分钟的68Ga-FAPI-04 PET成像是可行的,并且与SUVmax和SUVmean的60分钟成像高度相关.
- 早期成像提供可重现的定量数据,有可能改善患者的工作流程和扫描效率.
- 在15分钟和60分钟获得的SUVpeak,TLR和UTV定量值不应交替使用,因为可重复性较低.
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