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在休运动员和心血管风险之间的类固醇-雄激素类固醇
Sean Meagher1,2, Michael S Irwig3, Prashant Rao1,2
1Division of Cardiovascular Medicine.
在运动员中使用安卓代谢类固醇 (AAS) 具有显著的心血管和多器官风险,包括心脏损伤和心脏突然死亡风险增加. 这些风险即使在AAS停止后仍然存在,这凸显了医疗监测的必要性.
科学领域:
- 心血管医学 心血管医学
- 运动医学 运动医学
- 内分泌学 在内分泌学.
背景情况:
- 在休运动员中,安卓代谢类固醇 (AAS) 的使用日益增加.
- 越来越多的人担心慢性AAS暴露的心血管和多器官后果未被充分认识到.
- 专注于非竞争性人群及其特定风险.
研究的目的:
- 审查慢性AAS暴露的心血管和多器官后果.
- 为了突出与非竞技运动员使用AAS相关的风险.
- 告知临床医生关于AAS使用对运动员的影响.
主要方法:
- 对AAS使用及其健康影响现有研究的文献综述.
- 对心血管影响的新兴证据的分析.
- 综合与多系统毒性相关的发现.
主要成果:
- 使用AAS可以增强肌肉质量和力量,但会导致多系统毒性 (内分泌,肝脏,情绪).
- 显著的心血管影响包括高血压,不良脂质谱,加速动脉样硬化,心肌病,心肌梗塞和心脏突然死亡风险增加.
- 报告了结构和功能性心脏异常 (左心室缩,功能障碍,动脉硬),一些变化是持久的.
结论:
- 使用AAS存在多系统风险,包括不良的心血管改造和动脉动脉生成.
- 临床医生应确定AAS使用模式,提供风险分层,监测和逐渐减少策略.
- 未来的研究需要关注长期结果,性别特异性影响和多学科护理.
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