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早期发生的消化系统恶性疾病的全球流行病学:对全球疾病负担的系统分析 2021年研究
Jiayi Wang1, Deming Li1, Fangzhou Ye1
1Endoscopy Center, Minhang District Central Hospital of Fudan University, Shanghai, China.
Journal of gastroenterology and hepatology
|May 22, 2025
概括
早期发病的消化系统癌症在全球范围内表现出不同的趋势,一些发病率下降,但死亡率和DALY率整体下降. 风险因素包括饮食,烟草和酒精,这突显了严重的公共卫生问题.
科学领域:
- 全球卫生流行病学
- 在瘤学瘤学.
- 公共卫生研究 公共卫生研究
背景情况:
- 关于年轻人消化系统癌症的全球负担的研究有限.
- 早期发病的消化系统恶性病被定义为在50岁之前被诊断出来的癌症.
- 这项研究解决了对这种日益增长的担忧的全面数据的需求.
研究的目的:
- 通过使用2021年全球疾病负担数据,全面调查早期发病的消化系统恶性瘤的全球负担.
- 分析主要早期发病的消化道癌的发病率,流行率,死亡率和残疾调整寿命年 (DALYs) 的趋势.
- 确定关键的风险因素,并预测未来的疾病负担.
主要方法:
- 利用的全球疾病负担 (GBD) 2021年发生率,流行率,死亡率,DALY和风险因素的数据.
- 分析了五种主要的早期发作的消化系统恶性瘤:食道,胃,肝脏,胰腺和结肠直肠癌.
- 对于未来预测的平均年均百分比变化 (AAPC) 和贝叶斯年龄周期队列 (BAPC) 模型的就业结合点回归.
主要成果:
- 从1990年到2021年,大多数早期发病的消化道癌的年龄标准化发病率 (ASIR) 减少,除了早期发病的结直肠癌 (EOCRC).
- 年龄标准化死亡率和DALYs率显示,在早期发作的消化系统恶性瘤中出现下降趋势.
- 高中级社会人口指数 (SDI) 的国家表现出更高的疾病负担,饮食,烟草,酒精和代谢因素被确定为主要风险.
结论:
- 早期发病的消化系统恶性瘤根据性别,地理位置和特定的癌症类型表现出显著的差异.
- 预测趋势表明,到2030年,早发食道癌 (EOEC) 和EOCRC的ASIR将增加.
- 解决早期出现的消化系统恶性瘤的公共卫生挑战需要有针对性的干预和持续的研究.
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