在野生灵长类动物群体中,在婴儿期内,肠道病毒的获取增加
India A Schneider-Crease1,2,3, Isabella L Moya1,4, Kenneth L Chiou1,4
1Center for Evolution and Medicine, Arizona State University, Tempe, Arizona, USA.
Molecular ecology
|May 22, 2025
概括
类似于Crassphage的病毒,肠杆病毒,由婴儿格拉达在10个月左右获得,在断奶时达到顶峰. 雨量和饮食等环境因素影响它们的流行率和与肠道微生物群的相互作用.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 灵长类生态学灵长类生态学
背景情况:
- 肠道病毒,包括crAssphages,在人类肠道病毒组中大量存在,并影响健康.
- 由于环境和饮食的变化,婴儿的获取模式不明.
- 研究非人类灵长类动物提供了对生命早期病毒获取和宿主微生物相互作用的见解.
研究的目的:
- 调查婴儿格拉达中的肠杆菌的获取模式和患病率.
- 探索环境因素,饮食和肠道病毒存在之间的关系.
- 了解肠道病毒如何与野生灵长类动物模型中的发育中的肠道微生物群相互作用.
主要方法:
- 分析婴儿和母果拉达在婴儿时期的便样本.
- 基因组识别和特征的crassphage-like病毒 (Intestiviridae).
- 病毒流行,年龄,降雨量和饮食变化之间的相关性分析.
主要成果:
- 确定了8种与人类crAssphages密切相关的肠道病毒基因组.
- 肠道病毒的患病率在10个月左右增加,在断奶时达到顶峰 (约18个月),在成年人中仍然很高.
- 较高的降雨量和草的可用性与增加的肠道病毒检测有关.
- 肠道病毒动态与 Bacteroidales 种群的变化相关,包括糖降解剂的减少和发酵细菌的增加.
结论:
- 格拉达婴儿获得肠道病毒,其患病率与发育和季节性变化有关.
- 雨量和饮食等环境因素显著影响肠道病毒的获取和丰富性.
- 肠道病毒-细菌宿主关系可能与宿主发育和肠道微生物群的饮食转变相互作用.
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