-有机框架和复合物凝支架具有双抗氧化活性,用于增强骨再生
Yao Lu1, Lan Zhang2, Bin Yang1
1Department of Orthopedic, Northern Jiangsu People's Hospital Affiliated Hospital to Yangzhou University, Yangzhou 225009, China.
ACS applied materials & interfaces
|May 22, 2025
概括
这项研究引入了一种新的复合水凝支架 (Gel/Alg@Ce-Res/PDA),用于修复骨缺陷. 它有效地减少氧化应激,促进骨愈合,提供有前途的临床应用.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科工程 整形外科工程
- 再生医学是一种再生医学.
背景情况:
- 由于传统骨替代品的局限性,大型骨缺陷带来了重大的骨科挑战.
- 开发先进的生物材料对于有效的骨修复和再生至关重要.
研究的目的:
- 开发一种新型的复合水凝支架 (Gel/AlgMA),载有金属有机框架 (Ce-UiO-66) 和复星 (Res),以应对骨缺陷中的氧化应激.
- 评估复合脚手架的抗氧化剂,生物相容性和骨质性潜力,以改善骨缺陷的修复.
主要方法:
- 制造一种凝/酸盐双网络水凝支架 (Gel/AlgMA),其中包含Ce-UiO-66和化 (Res),涂有多多巴胺 (PDA).
- 用于支架制备的光聚合技术.
- 在体外评估生物相容性,抗氧化能力 (ROS清除) 和骨质性潜力.
- 在体内评估脚手架在骨缺陷修复中的有效性.
主要成果:
- 凝/Alg@Ce-Res/PDA复合脚手架展示了显著的活性氧物种 (ROS) 清理能力,缓解了局部氧化应激.
- 在体外研究证实了优良的生物相容性,增强骨质母细胞的增殖和分化.
- 在体内实验验证了脚手架在促进骨缺陷愈合方面的有效性.
结论:
- 开发的Gel/Alg@Ce-Res/PDA复合脚手架是一个有前途的创新生物材料,通过管理微环境来治疗骨缺陷.
- 该研究强调了将抗氧化剂释放的MOF和天然化合物结合在骨科应用的水凝中的潜力.
相关概念视频
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:23Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
01:18The Bone Matrix
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...