引入两种用于评估冠状动脉狭窄的新指数:动脉动脉炎症指数和动脉动脉炎症葡萄糖指数
Rana Kolahi Ahari1,2, Mohsen Moohebati3, Mohammad Tajfard4
1Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of clinical laboratory analysis
|May 22, 2025
概括
新的阿瑟罗炎症 (AI) 和阿瑟罗炎症葡萄糖 (AIG) 指数显示与冠状动脉狭窄症 (CAS) 有着强烈的关联. 这些指数有效地将CAS患者与健康个体区分开来,表明它们作为诊断生物标志物的潜力.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 诊断医学 诊断医学 诊断医学
背景情况:
- 冠状动脉狭窄 (CAS) 诊断依赖于各种指标.
- 新的阿瑟罗炎症 (AI) 和阿瑟罗炎症葡萄糖 (AIG) 指数需要调查它们与CAS的关联.
研究的目的:
- 调查AI和AIG指数与冠状动脉狭窄症 (CAS) 的关联.
- 评估AI和AIG指数在识别CAS的诊断性能.
主要方法:
- 一项涉及2326名参与者的病例控制研究 (血管造影阳性,血管造影阴性和健康对照).
- 使用ANOVA的组之间AI和AIG指数的比较.
- 后勤回归和ROC曲线分析以评估关联和诊断准确性.
主要成果:
- 在所有组中,AI和AIG指数显著不同 (p < 0.001).
- 这两种指数在调整混因子后,独立地与血管造影阳性结果相关.
- ROC分析表明AI (AUC:0.895) 和AIG (AUC:0.918) 的高诊断性能,在将CAS与健康受试者区分开来.
结论:
- 人工智能指数在区分CAS方面表现优于其他生物标志物.
- 结合AI和禁食葡萄糖的AIG指数是CAS识别的有希望的指标,特别是在与健康人群区分时.
更多相关视频
相关概念视频
Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Acute Coronary Syndrome I: Introduction
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Atherosclerosis I: Introduction
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...


