在童年症解决后,年轻成年人的认知结果
Jacob Megreli1,2,3, Leo Arkush3,4, Estela Derazne5
1Medical Corps, Israel Defense Forces, Ramat-Gan, Israel.
Annals of neurology
|May 22, 2025
概括
患有的儿童可能面临长期的认知挑战. 以前被诊断患有童年的年轻人即使在没有和未服用药物后,也显示出低认知功能的可能性增加.
科学领域:
- 神经学 神经学
- 儿科神经学 儿科神经学
- 认知神经科学 认知神经科学
背景情况:
- 童年自限性经常被认为是良性疾病.
- 儿童患者的长期认知结果尚未完全理解.
- 以前的研究还没有在没有发作,没有药物治疗的年轻成年人中广泛评估儿童的认知功能.
研究的目的:
- 与一般人群相比,研究有儿童史的年轻成年人的认知功能差异.
- 为了确定发作缓解和停止抗发作药物是否能使认知功能正常化.
- 根据长期的认知后果,挑战将某些儿童作为"良性"的分类.
主要方法:
- 横截面,基于人群的研究设计.
- 包括一个大型队列,包括2,124,871名16至19岁的男女.
- 分析了3,452名参与者的认知功能,他们没有发作超过5年,没有药物治疗超过2年,使用多项回归.
主要成果:
- 患有童年史的参与者,尽管没有发作和未服用药物,但对认知功能低下的概率比率 (OR) 为1.44 (95% CI = 1.24-1.68,p < 0.001).
- 这一发现表明,儿童和以后的认知障碍之间存在统计学意义上的关联.
- 结果是强大的,利用大样本大小和适当的统计建模.
结论:
- 鉴于观察到的长期认知影响,儿童的"良性"术语应该重新考虑.
- 儿童可能对认知功能产生持久的影响,延伸到年轻成人.
- 需要进一步的研究,以了解这一群体认知缺陷背后的机制.
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