肠道机会性病原体通过提高溶酸胆和诱导炎症,导致高海拔肺
Xianduo Sun1, Gaosheng Hu1, Yuting Li2
1Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Microbiology spectrum
|May 22, 2025
概括
肠道细菌会影响高海拔肺 (HAPE). 特定的细菌,如Klebsiella和大肠杆菌恶化HAPE,而共生菌通过降低炎症和溶酸胆水平来提供保护.
科学领域:
- 微生物学 微生物学
- 身体生理学 身体生理学
- 高度医学 高度医学
背景情况:
- 已知肠道微生物群在缺氧引起的肠道损伤中的作用.
- 肠道微生物群对高海拔肺 (HAPE) 的参与以及协生菌的保护作用仍然不清楚.
研究的目的:
- 研究肠道微生物群在HAPE病变发生中的作用.
- 探索HAPE.的共生预防的基础机制.
主要方法:
- 在人类从急性山病 (AMS) 恢复后的便微生物组分析.
- 在老鼠和小鼠中使用特定的肠道细菌和酸胆 (LPC) 在模拟高海拔 (6,500米) 上诱导HAPE.
- 在体外细胞实验和分子动力学模拟在内皮细胞和上皮细胞.
主要成果:
- 在AMS恢复期间观察到肠道Klebsiella和Escherichia-Shigella减少,Bifidobacterium和Lactobacillus增加.
- 通过增加血炎症和LPCs,与Klebsiella pneumoniae和Escherichia coli的殖民化在老鼠中加剧了HAPE.
- 在大鼠中,同生菌治疗显著减轻了HAPE严重程度.
- 肺内皮细胞 (LPC) 损害了肺内皮和上皮细胞,在缺氧下增加了透性.
- 在小鼠中,LPC的使用促进了HAPE.
结论:
- 一个新的肠道微生物群-LPCs/炎症-HAPE轴被确定.
- 这个轴为HAPE病原体提供了新的见解.
- 这些发现可能会为HAPE的新型预防和治疗策略提供信息.
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