干细胞标记物的关联与良性乳腺组织的叶状内卷
Lusine Yaghjyan1, Rulla M Tamimi2, Gabrielle M Baker3
1University of Florida, Gainesville, United States.
概括
乳腺组织中较高的CD44和ALDH1A1干细胞标志物表达与终端导管叶状单元卷积的减少有关,这表明它在降低乳腺癌风险方面发挥了作用.
科学领域:
- 乳腺癌研究研究 乳腺癌研究
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 最终导管叶片单元 (TDLU) 卷积与乳腺癌风险降低有关.
- 乳腺干细胞 (SCs) 在TDLU发育中的作用尚不清楚.
研究的目的:
- 为了研究乳腺干细胞标记物 (CD44,CD24,ALDH1A1) 和TDLU发育之间的关联.
- 通过TDLU发育,探索SCs对乳腺癌风险的潜在影响.
主要方法:
- 这项研究包括309名患有良性乳腺疾病的无癌症妇女.
- 免疫组织化学 (IHC) 评估了SC标志物 (CD44,CD24,ALDH1A1) 的表达.
- 计算病理学分析了TDLU进化指标.
- 统计分析使用了通用线性回归模型.
主要成果:
- 较高的CD44表达与上升的皮细胞数量和密度相关,无论是在上皮组织还是肌层组织中.
- 较高的ALDH1A1表达与较高的中位数acini密度 (上皮) 和每TDLU的acini计数 (流体) 相关.
- CD44和ALDH1A1都显示出与TDLU卷变的措施的积极关联.
结论:
- 乳腺组织中CD44和ALDH1A1的表达增加与减少TDLU卷积有关.
- 这项研究提供了第一个流行病学证据,将SC标记物与TDLU卷变联系起来.
- 这些发现可能为通过干细胞活性和TDLU变化对乳腺癌风险调节提供见解.
相关概念视频
Overview of Secretory Vesicles
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Renewal of Intestinal Stem Cells
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Microvilli
Microvilli are tiny finger-like projections found on the surface of certain cells. Their purpose is to increase the surface area of the cell's apical surface, resulting in more effective absorption or secretion of substances.
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity to...
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity to...
Cells and Secretions of the Pancreas
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Histology of the Small Intestine
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...


