功能多样化的转子体的水平传播是新的内子体的主要来源
Landen Gozashti1,2,3, Anne Nakamoto4,5, Shelbi Russell4,5
1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.
概括
可转移的元素称为内子,在真核基因组中驱动新的内增益. 巨型病毒也可能促进跨物种的内部转移,解释基因组进化.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 分子生物学分子生物学
背景情况:
- 在真核基因组中结合体内基因的起源和传播尚未完全理解.
- 专门的可转换元素 (TEs),称为内质子,是假设的内质子增益的驱动因素.
- 内体传播的精确分子机制和进化途径仍然难以捉摸.
研究的目的:
- 研究分子和进化过程驱动在真核生物中的内子增益.
- 为了识别作为内置物作用的可转移元素的多样性.
- 阐明内部传播和物种间转移的机制.
主要方法:
- 分析了8716个真核生物基因组,涵盖了17亿年的进化历史.
- 识别和分类的内家族.
- 在不同的宿主物种之间追踪内转移事件.
主要成果:
- 在201个物种中发现了1093个内生家族.
- 内部子源于各种可转移的元素家族,包括DNA TEs,逆转移子,密码子和子.
- 鉴定了8例不同物种之间最近的内体转移案例,其中巨型病毒涉及促进跨血统转移.
结论:
- 可转移元素的活性是真核生物中持续的内子增益的主要驱动因素.
- 这项研究解决了基因组结构进化的关键.
- 巨型病毒可能在横向转移内基因中发挥重要作用,影响跨血统的基因组进化.
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