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Updated: May 23, 2025

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鉴定涉及PARP-1抑制剂耐药性的新基因表达模式和途径

Zulfa Khan1, Anish Gomatam1, Upadhyayula Suryanarayana Murty1

  • 1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, (NIPER Guwahati), Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India, Sila Katamur (Halugurisuk), P.O.: Changsari, Dist: Kamrup, Guwahati, Assam, 781101, India.

Mammalian genome : official journal of the International Mammalian Genome Society
|May 22, 2025
PubMed
概括

研究人员确定了与BRCA1/2-突变乳腺癌和卵巢癌中Olaparib耐药性相关的新基因特征. 这些发现提供了克服治疗耐药性的潜在生物标志物.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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