使用新型内核k-means机器学习算法进行治疗旅程集群:对双相I型精神障碍患者的保险索赔进行回顾性分析
Matthew Littman1, Huy-Binh Nguyen2, Joanna Campbell2
1AbbVie, North Chicago, IL, USA. matthew.littman@abbvie.com.
Brain informatics
|May 22, 2025
概括
一个新的算法,使用Kernel K-means for Event Sequences (DOCKKES) 的Divisive Optimized Clustering,有效地集群复杂的患者治疗过程. 这种方法揭示了双相I型精神障碍治疗的独特模式,有助于现实世界结果分析.
科学领域:
- 精神病学流行病学精神病学流行病学
- 计算生物学是一种计算生物学.
- 医疗服务研究 医疗服务研究
背景情况:
- 现实世界的精神病治疗涉及复杂,多样化的患者旅程,各种诊断和疗法.
- 在保险索赔数据中分析这些复杂的事件序列是现有方法的挑战.
研究的目的:
- 开发一种新的算法,使用Kernel K-means for Event Sequences (DOCKKES) 的Divisive Optimized Clustering,用于分析各种事件序列.
- 评估DOCKKES在为双相I型精神障碍患者识别不同的治疗旅程集群方面的表现.
主要方法:
- 开发了DOCKKES,这是一个用于事件序列的内核k-means集群算法,它包含了一个新的过渡得分指标.
- 应用DOCKKES对使用MarketScan®商业数据库保险索赔的31578名双相I型精神障碍患者的回顾性分析.
- 确定双极性情节诊断和心理健康治疗线作为聚类的关键事件.
主要成果:
- 在双相I型精神障碍患者中,DOCKKES确定了16个不同的治疗旅程集群,75%的人经历了独特的途径.
- 根据最初的躁狂/混合或抑郁情节 (8个) 均均分组,并显示序列长度和早期治疗的变化.
- 在人口统计,并发症,医疗保健利用率和成本方面,在各个集群中观察到显著的变化.
结论:
- DOCKKES是一种新且有效的方法,用于分析大规模医疗保险索赔数据中的复杂,异质的患者治疗过程.
- 已识别的集群为I型双相情感障碍的现实世界治疗变异提供了洞察力,促进了结果比较和指导方针评估.
更多相关视频
04:09Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
Published on: October 10, 2018
8.2K
14:27Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
15.6K
相关概念视频
Bipolar Disorder
41
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
41
Mania and Antimanic Drugs: Overview
106
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
106
Treatment Strategies for Psychological Disorders
79
Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
79
