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自介导的免疫反应调节和癌症中抗药性
Anupriya Bandyopadhyay1, Samraj Sinha1, Rajdeep Roy1
1Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.
Molecular biology reports
|May 22, 2025
概括
自会影响癌症药物耐药性和免疫抑制. 这篇评论详细介绍了自如何调节瘤微环境中的表观遗传变化和免疫细胞功能,从而影响癌症的进展.
科学领域:
- 细胞生物学 细胞生物学
- 癌症研究 癌症研究
- 免疫学 免疫学 免疫学
背景情况:
- 自对于细胞平衡至关重要,在衰老,感染,炎症和癌症等条件下平衡细胞生存和死亡.
- 癌症治疗面临着来自多药性耐药性和免疫抑制的挑战,自性发挥着复杂的作用.
- 自与亡和增殖信号相互作用,影响化疗结果和耐药性.
研究的目的:
- 审查瘤微环境中自细胞在调解药物耐药性和免疫调节方面的双重作用.
- 巩固最近关于自细胞参与表观遗传修饰和免疫细胞在各种癌症中的分化方面的发现.
- 为了提供对自对致癌的影响的全面概述.
主要方法:
- 关于自在癌症中的作用的最新研究的文献综述.
- 对自的参与药物耐药机制的分析,包括表观遗传变化 (miRNAs, lncRNAs).
- 检查瘤微环境 (TME) 内的免疫细胞分化和调节中的自的功能.
主要成果:
- 自会通过表观遗传修饰和在肺癌和乳腺癌中改变非编码RNA表达来促进多种药物耐药性 (例如,西斯普拉丁,文克里斯,塔莫西芬).
- 异常的自水平通过增殖信号和与亡的相互作用与耐药性有关.
- 自参与TME中各种免疫细胞 (巨细胞,T细胞,B细胞,DC细胞,中性粒细胞,纤维细胞) 的分化和功能,影响癌症发生.
结论:
- 自通过调节药物耐药性和免疫反应,显著影响癌症的进展.
- 了解自介导表观遗传调节和免疫相互作用对于开发新型癌症疗法至关重要.
- 这篇综述强调了自在逃避癌症治疗和塑造瘤免疫格局方面发挥的关键,多方面的作用.
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